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Merck

100073

15-PGDH Inhibitor

The 15-PGDH Inhibitor controls the biological activity of 15-PGDH. This small molecule/inhibitor is primarily used for Membrane applications.

Synonym(s):

15-PGDH Inhibitor, 5-(4-(2-Cyclohexylethoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione

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About This Item

Empirical Formula (Hill Notation):
C19H23NO4S
CAS Number:
1239610-60-6
Molecular Weight:
361.46
UNSPSC Code:
51111800
NACRES:
NA.77

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Product Name

15-PGDH Inhibitor, The 15-PGDH Inhibitor controls the biological activity of 15-PGDH. This small molecule/inhibitor is primarily used for Membrane applications.

InChI

1S/C19H23NO4S/c1-23-16-11-14(12-17-18(21)20-19(22)25-17)7-8-15(16)24-10-9-13-5-3-2-4-6-13/h7-8,11-13H,2-6,9-10H2,1H3,(H,20,21,22)/b17-12-

InChI key

REFPRDWFDSQKAG-ATVHPVEESA-N

SMILES string

O=C(NC/1=O)SC1=C/C2=CC=C(OCCC3CCCCC3)C(OC)=C2

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 100 mg/mL, clear, pale yellow

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Related Categories

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable, thiazolidinedione derivative that acts as a 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor (IC50 = 25 nM). It is shown to increase PGE2 levels in IL-1β-stimulated A549 cells, dose-dependently, in the range of 0–20 µM, and elicits cochlear blood flow (CBF) increase by 15% and 55% when applied intravenously to 250 g guinea pigs at 10 µg and 20 µg respectively.

Other Notes

Wu, Y., et al. 2011. J. Med. Chem.54, 5260.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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