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Merck

1.07025

Tetrahydrofuran

≥99.5% (GC), EMPARTA® ACS reagent

Synonym(s):

THF, Tetramethylene oxide, Oxolane, Butylene oxide, Butylene oxide, Oxolane, Tetramethylene oxide

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About This Item

Empirical Formula (Hill Notation):
C4H8O
CAS Number:
Molecular Weight:
72.11
NACRES:
NB.21
EC Index Number:
203-726-8
UNSPSC Code:
12191504
MDL number:
Beilstein/REAXYS Number:
102391
grade:
ACS reagent
assay:
≥99.5% (GC)
bp:
65-67 °C (lit.)
vapor pressure:
114 mmHg ( 15 °C)
143 mmHg ( 20 °C)

Product Name

Tetrahydrofuran, for analysis EMPARTA® ACS

InChI key

WYURNTSHIVDZCO-UHFFFAOYSA-N

SMILES string

C1CCOC1

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2

grade

ACS reagent

vapor density

2.5 (vs air)

vapor pressure

114 mmHg ( 15 °C)
143 mmHg ( 20 °C)

product line

EMPARTA®

assay

≥99.5% (GC)

form

liquid

autoignition temp.

610 °F

expl. lim.

1.8-11.8 %

dilution

(for routine analytical applications)

impurities

≤0.01% Peroxide (as H2O2)
≤0.05% Water

evapn. residue

≤0.03%

color

clearAPHA: ≤10

refractive index

n20/D 1.407 (lit.)

pH

7-8 (20 °C, 200 g/L in H2O)

bp

65-67 °C (lit.)

mp

−108 °C (lit.)

transition temp

flash point -21.5 °C

density

0.889 g/mL at 25 °C (lit.)

storage temp.

2-30°C

Quality Level

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Analysis Note

Purity (GC): ≥ 99.5 %
Identity (IR): conforms
Appearance: clear
Color: ≤ 10 Hazen
Peroxide (as H₂O₂): ≤ 0.01 %
Evaporation residue: ≤ 0.03 %
Water: ≤ 0.05 %
Stabilized with 2,6-Di-tert-butyl-4-methylphenol (BHT).

Application



  • Phenylalanine Ammonia Lyase Activity Research: A study investigated the mutase-like activity of phenylalanine ammonia lyase from Anabaena variabilis, demonstrating the utility of buffer concentrate in biochemical assays to stabilize enzyme activity during the research (Weise et al., 2018).


  • Studying Amyloid Precursor Protein: A study used buffer concentrate for experiments involving the amyloid precursor protein C-terminal fragment C100, noting its importance in maintaining the stability of protein conformations during interactions with γ-secretase modulators (Botev et al., 2011).




General description

EMD Millipore offers EMPARTA grade solvents for routine tasks in analytical laboratories. EMPARTA grade solvents offer fewer test parameters than EMSURE, yet are still of high quality. EMPARTA solvents meet ACS requirements, making them ideal for a wide range of analytical applications.
EMPARTA solvents are designed for routine chemical synthesis, drying, purification, and critical labware cleaning in quality control environments. Engineered for precision, they deliver consistently reproducible results essential for rigorous validation and documentation.

Exceptional Quality Standards: These solvents meet or exceed ACS specifications, providing assurance of high quality that is crucial for accurate testing and analysis in quality control.

Consistent Reproducibility: Designed for precision, the solvents ensure that results can be reliably reproduced, which is vital for maintaining compliance and integrity in quality control processes.

Versatile Applications: Suitable for a variety of QC tasks, including analytical testing, method validation, and testing USP/NF monographs, these solvents support a comprehensive approach to quality assurance in laboratory settings.

Legal Information

EMPARTA is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system, Respiratory system

supp_hazards

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

-6.2 °F - closed cup

flash_point_c

-21.2 °C - closed cup


Certificates of Analysis (COA)

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