Acidic Mammalian Chitinase Inhibitor, Bisdionin F

Name: Acidic Mammalian Chitinase Inhibitor, Bisdionin F
Brand: MM

The Acidic Mammalian Chitinase Inhibitor, Bisdionin F controls the biological activity of Acidic Mammalian Chitinase.

Synonym(s):

Acidic Mammalian Chitinase Inhibitor, Bisdionin F, AMCase Inhibitor, 3,7-dimethyl-1-(3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)propyl)-1H-purine-2,6(3H,7H)-dione

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₈N₈O₄

CAS Number:

917877-86-2

Molecular Weight:

386.37

UNSPSC Code:

12352106

NACRES:

NA.54

Quality Level

100

Assay

≥95% (HPLC)

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 5 mg/mL, clear, nearly colorless

shipped in

ambient

storage temp.

2-8°C

SMILES string

CN(C=N1)C2=C1N(C)C(N(C2=O)CCCN3C(N(C)C(N=CN4)=C4C3=O)=O)=O

InChI key

PUHJHZQYIBJCSQ-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecule Inhibitors

General description

A cell-permeable, competitive Acidic Mammalian Chitinase (AMCase) Inhibitor (IC₅₀ = 0.92 µM and K_i = 0.42 µM for hAMCase, and IC₅₀= 2.2 µM for mAMCase, in vitro) that demonstrates 20-fold selectivity for hAMCase over hCHIT1. It is shown to decrease chitinase enzymatic activity (5 mg/kg, i.p.) in the lungs of control PBS- and OVA-challenged mice. Furthermore, it attenuates lung chitinase activity, reduces eosinophil influx, and improves ventilatory function, in vivo, in a murine model of allergic inflammation. It also causes neutrophilia in the lungs of OVA-challenged mice.

Packaging

Packaged under inert gas

Other Notes

Sutherland, T.E., et al. 2011. Chem. Biol.18, 569.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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