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Adenosine 5′-O-(3-Thiotriphosphate), Tetralithium Salt

Name: Adenosine 5′-O-(3-Thiotriphosphate), Tetralithium Salt
Brand: MM

A relatively stable, slowly hydrolyzable ATP analog that can substitute for ATP in various kinase reactions. Used as a substrate and as an inhibitor of ATP-dependent enzyme systems.

Synonym(s):

Adenosine 5′-O-(3-Thiotriphosphate), Tetralithium Salt, ATP-γ-S, 4Li

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₂N₅O₁₂P₃S · 4Li

CAS Number:

93839-89-5

Molecular Weight:

546.98

UNSPSC Code:

12352208

NACRES:

NA.51

MDL number:

MFCD00077293

Form:

solid

Assay:

≥85% (HPLC)

Solubility:

water: 10 mg/mL

Color:

white

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Properties

Quality Segment

100

assay

≥85% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

impurities

<10% ADP

color

white

solubility

water: 10 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

[Li+].[Li+].[Li+].[Li+].[P](=O)([S-])([O-])O[P](=O)([O-])O[P](=O)([O-])OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)[n]2c3ncnc(c3nc2)N

InChI

1S/C10H16N5O12P3S.4Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31;;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31);;;;/q;4*+1/p-4/t4-,6-,7-,10-;;;;/m1..../s1

InChI key

DWQFDOIBOYDYKH-KWIZKVQNSA-J

Description

General description

A relatively stable, slowly hydrolyzable ATP analog that can substitute for ATP in various kinase reactions. Increases the activity of Ca²⁺-activated K⁺ channels. Used as a substrate and as an inhibitor of ATP-dependent enzyme systems.

Application

Involvement of purinergic receptors and NOD-like receptor-family protein 3-inflammasome pathway in the adenosine triphosphate-induced cytokine release from macrophages.: This study explores the role of purinergic receptors and the NOD-like receptor-family protein 3 (NLRP3) inflammasome pathway in cytokine release induced by adenosine triphosphate (ATP) in macrophages. The findings suggest potential therapeutic targets for inflammatory diseases (Gicquel et al., 2014).

Extracellular ATP facilitates flow-induced vasodilatation in rat small mesenteric arteries.: The study demonstrates that extracellular ATP enhances flow-induced vasodilation in small mesenteric arteries in rats, indicating a significant role of ATP in vascular function and potential implications for cardiovascular therapies (Liu et al., 2004).

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 3 months at -20°C.

Other Notes

Troadec, J.D., et al. 1999. Pflugers Arch. 437, 745.
Chung, S., et al. 1991. Science253, 560.
Litosch, I., and Fain, J.N. 1986. Life Sci. 39, 187.
Chrysogelos, S., et al. 1983. J. Biol. Chem.258, 12624.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c