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Merck

126850

α1-PDX, Human, Recombinant, E. coli

Recombinant protein derived from the bioengineered human α1-antitrypsin gene fused to a His•Tag sequence and a FLAG-tag.

Synonym(s):

α1-Antitrypsin Portland

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥80% (SDS-PAGE)
Form:
lyophilized solid
Quality level:
100
Storage condition:
do not freeze

Key Documents

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Product Name

α1-PDX, Human, Recombinant, E. coli, Recombinant protein derived from the bioengineered human α1-antitrypsin gene fused to a His•Tag sequence and a FLAG-tag.

assay

≥80% (SDS-PAGE)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

do not freeze

solubility

water: 2.5 mg/mL

shipped in

wet ice

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: no
Primary Target
Furin-dependent processing of protein precursors
Product does not compete with ATP.
Reversible: no
Target Ki: 600 pM against furin-dependent processing of protein precursors

Disclaimer

Toxicity: Standard Handling (A)

General description

Recombinant protein derived from the bioengineered human α1-antitrypsin gene fused to a His•Tag sequence and a FLAG-tag. Contains a minimal furin consensus sequence, RXXR, that effectively blocks the furin-dependent processing of protein precursors (Ki = 600 pM). Extracellular application of α1-PDX can be used to inhibit the processing of biologically significant proteins including viral envelope glycoproteins, bacterial toxins, receptors, and growth factors. Useful for in vivo and in vitro furin inhibition assays.

Other Notes

Bassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA98, 10326.
Jean, F., et al. 2000. Proc. Natl. Acad. Sci. USA97, 2864.
Jean, F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 7293.

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

Lyophilized from PBS.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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