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126920

Alda-1

The ALDH2 Agonist, Alda-1, also referenced under CAS 349438-38-6, controls the biological activity of ALDH2. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

Synonym(s):

ALDH2 Agonist, Alda-1, N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide

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About This Item

Empirical Formula (Hill Notation):
C15H11Cl2NO3
CAS Number:
349438-38-6
Molecular Weight:
324.16
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD02055160
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
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Product Name

ALDH2 Agonist, Alda-1, The ALDH2 Agonist, Alda-1, also referenced under CAS 349438-38-6, controls the biological activity of ALDH2. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white

solubility

ethanol: 10 mg/mL, DMSO: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Clc1c(c(ccc1)Cl)C(=O)NCc2cc3c(cc2)OCO3

InChI

1S/C15H11Cl2NO3/c16-10-2-1-3-11(17)14(10)15(19)18-7-9-4-5-12-13(6-9)21-8-20-12/h1-6H,7-8H2,(H,18,19)

InChI key

NMKJFZCBCIUYHI-UHFFFAOYSA-N

General description

A cell-permeable benzamide compound that selectively enhances the activity of both the wild-type ALDH2*1 and the east asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (2.1-, 2.2, and 11-fold activation of 20 µg wt homo, wt/mut hetero, and mut homo tetramer, respectively, at 100 µM), while exhibiting no effect toward alcohol dehydrogenase 1, cytosolic ALDH1, or mitochondrial ALDH5. Both PKCε activatior- and ethanol-mediated protections against heart tissue ischemic damage are reported to correlate well with ALDH2 activation, and Alda-1, likewise, is shown to protect against ischemic tissue damage to excised rat hearts (26% and 24% reduction in infarct size and CPK release, respectively; 20 µM) ex vivo and anesthetized live rats (60% infarction reduction; 8.5 mg/kg) in vivo.

Packaging

Packaged under inert gas

Preparation Note

Following, reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Chen, C.H., et al. 2008. Science321, 1493.

Legal Information

Patent pending.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Storage Class

11 - Combustible Solids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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