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Merck

138000

D-Amino Acid Oxidase Inhibitor

The D-Amino Acid Oxidase Inhibitor, also referenced under CAS 39793-31-2, controls the biological activity of D-Amino Acid Oxidase.

Synonym(s):

D-Amino Acid Oxidase Inhibitor, 4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, D-AAO Inhibitor, Compound 8

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About This Item

Empirical Formula (Hill Notation):
C7H5NO2S
CAS Number:
39793-31-2
Molecular Weight:
167.19
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze
protect from light

Key Documents

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Product Name

D-Amino Acid Oxidase Inhibitor, The D-Amino Acid Oxidase Inhibitor, also referenced under CAS 39793-31-2, controls the biological activity of D-Amino Acid Oxidase.

InChI key

PMHDSACGRKBACK-UHFFFAOYSA-N

InChI

1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10)

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

beige

solubility

5% NaOH: 25 mg/mL
DMSO: 80 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Disclaimer

Toxicity: Harmful (C)

General description

A cell-permeable thienopyrrole compound that potently inhibits the cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC50 against human and rat DAO = 145 and 114 nM, respectively), while exhibiting no activity towards D-aspartate oxidase (DDO; IC50 >5 µM), P450 enzymes CYP3A4/2D6/3C9 (IC50 >10 µM), and a panel of over 150 other enzymes, receptors, and ion channels. Although in vivo treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects.

Other Notes

Smith, S.M., et al. 2009. J. Pharmacol. Exp. Ther.328, 921.
Sparey, T., et al. 2008. Bioorg. Med. Chem. Lett.18, 3386.

Packaging

Packaged under inert gas

Preparation Note

Unstable in solution; reconstitute just prior to use.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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