14-251-M

p38α/SAPK2a Protein, active, 10 µg

Name: p38α/SAPK2a Protein, active, 10 µg
Brand: MM

Active, N-terminal GST tagged, recombinant, full length p38α/SAPK2a, for use in Kinase Assays.

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.41

eCl@ss:

32160405

Product Name

p38α/SAPK2a Protein, active, 10 µg, Active, N-terminal GST tagged, recombinant, full length p38α/SAPK2a, for use in Kinase Assays.

biological source

human

recombinant

expressed in E. coli

mol wt

M_w 67.7 kDa

manufacturer/tradename

Upstate^®

technique(s)

activity assay: suitable (kinase)

Analysis Note

Routinely evaluated by phosphorylation of MBP

Biochem/physiol Actions

Protein Target: p38α/SAPK2a

Target Sub-Family: CMGC

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

N-terminal GST tagged, recombinant, full length p38α/SAPK2a

Product Source: expressed in E. coli

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Packaging

Also available in 250μg size (2x125μg) - Call for pricing and availability. Please reference catalog number 14-251M when ordering the 250μg size.

Physical form

Glutathione-agarose

Preparation Note

6 months at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1

Storage Class

10 - Combustible liquids

wgk

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells.

Y N Doza et al.

FEBS letters, 364(2), 223-228 (1995-05-08)

A MAP kinase homologue, termed the reactivating kinase (RK), lies in a signalling pathway which mediates cellular responses to stress. Here we demonstrate that the stress-induced activation of the RK in human KB cells is accompanied by the phosphorylation of

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1.

A Cuenda et al.

FEBS letters, 364(2), 229-233 (1995-05-08)

A class of pyridinyl imidazoles inhibit the MAP kinase homologue, termed here reactivating kinase (RK) [Lee et al. (1994) Nature 372, 739-746]. We now show that one of these compounds (SB 203580) inhibits RK in vitro (IC50 = 0.6 microM)

A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway.

Ben-Levy, R, et al.

The Embo Journal, 13, 3302-3311 (1994)

Global Trade Item Number

SKU	GTIN
14-251M	04053252626845
14-251	04053252583414

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