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Merck

14-331-M

SGK1 (δ1-59, S422D) Protein, active, 6 µg

Active, N-truncated (missing N-terminal 60 amino acids), His-tagged, human SGK1 fusion protein, containing a S422D mutation, for use in Kinase Assays.

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
eCl@ss:
32160405

Product Name

SGK1 (δ1-59, S422D) Protein, active, 6 µg, Active, N-truncated (missing N-terminal 60 amino acids), His-tagged, human SGK1 fusion protein, containing a S422D mutation, for use in Kinase Assays.

biological source

human

mol wt

Mw 48 kDa

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

NM_005627.2

UniProt accession no.

O00141

Quality Level

100
300

Gene Information

human ... SGK1(6446)

Analysis Note

routinely evaluated by Kinase assay

Biochem/physiol Actions

Protein Target: SGK1
Target Sub-Family: AGC

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

N-truncated (missing Nterminal 60 amino acids), His-tagged, human SGK1 fusion protein, containing a S422D mutation
Product Source: expressed in Sf21 cells

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Physical form

Ni-NTA agarose

Preparation Note

1 year at -70°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1

Storage Class

10 - Combustible liquids

wgk

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Activation of NHE3 by dexamethasone requires phosphorylation of NHE3 at Ser663 by SGK1
Wang, Dongsheng, et al
American Journal of Physiology. Cell Physiology, 289, C802-C810 (2005)
Dana Yoo et al.
The Journal of biological chemistry, 278(25), 23066-23075 (2003-04-10)
The Kir1.1 (ROMK) subtypes of inward rectifier K+ channels mediate potassium secretion and regulate sodium chloride reabsorption in the kidney. The density of ROMK channels on the cortical collecting duct apical membrane is exquisitely regulated in concert with physiological demands.
T Kobayashi et al.
The Biochemical journal, 344 Pt 1, 189-197 (1999-11-05)
The catalytic domain of serum- and glucocorticoid-induced protein kinase (SGK) is 54% identical with protein kinase B (PKB) and, like PKB, is activated in vitro by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and in vivo in response to signals that activate phosphatidylinositol

Global Trade Item Number

SKUGTIN
14-33104053252328633

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