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Merck

14-378

MKK4/SKK1 Protein, inactive, 50 g

Unactive, recombinant mouse MKK4, corresponding to amino acids 35-397, fused to an N-terminal GST-tag, for use in Kinase Assays.

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
eCl@ss:
32160405

Product Name

MKK4/SKK1 Protein, inactive, 50 g, Unactive, recombinant mouse MKK4, corresponding to amino acids 35-397, fused to an N-terminal GST-tag, for use in Kinase Assays.

biological source

mouse

recombinant

expressed in E. coli

mol wt

Mw 65 kDa

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

NM_003010.2

UniProt accession no.

P45985

shipped in

dry ice

Quality Level

100

Gene Information

mouse ... MAP2K4(26398)

Analysis Note

routinely evaluated by phosphorylation of ATF2 substrate

Biochem/physiol Actions

Protein Target: MKK4
Target Sub-Family: STE

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Product Source: expressed in E. coli
Recombinant mouse MKK4, corresponding to amino acids 35-397, fused to an Nterminal GST-tag

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Physical form

GSH-agarose chromatography

Preparation Note

6 months at -20C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1

Storage Class

10 - Combustible liquids

wgk

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Eleanore A Gross et al.
The Journal of biological chemistry, 277(16), 13873-13882 (2002-02-12)
Mitogen-activated protein (MAP) kinase pathways are three-kinase modules that mediate diverse cellular processes and have been highly conserved among eukaryotes. By using a functional complementation screen in yeast, we have identified a human MAP kinase kinase kinase (MAPKKK) that shares
Luis Cedeno-Rosario et al.
The Journal of biological chemistry, 298(8), 102263-102263 (2022-07-18)
Mixed lineage kinase 3 (MLK3) is a serine/threonine mitogen-activated protein kinase kinase kinase that promotes the activation of multiple mitogen-activated protein kinase pathways and is required for invasion and proliferation of ovarian cancer cells. Inhibition of MLK activity causes G2/M

Global Trade Item Number

SKUGTIN
14-37804053252738623

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