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Merck

14-455

Rap1 Assay Reagent (Ral GDS-RBD, agarose), 650 µg

Reagent (Ral GDS-RBD, agarose). A GST-tagged fusion protein, corresponding to amino acids 788-884 of human Ral GDS-Rap binding domain (RBD), for use in Affinity Binding Assays.

Synonym(s):

Ral GDS-RBD Assay Reagent, Rap1 Detection Reagent

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About This Item

UNSPSC Code:
12352204
NACRES:
NA.41
eCl@ss:
32160405

Product Name

Rap1 Assay Reagent (Ral GDS-RBD, agarose), 650 µg, Reagent (Ral GDS-RBD, agarose). A GST-tagged fusion protein, corresponding to amino acids 788-884 of human Ral GDS-Rap binding domain (RBD), for use in Affinity Binding Assays.

biological source

human

form

liquid

manufacturer/tradename

Upstate®

technique(s)

affinity binding assay: suitable

NCBI accession no.

NM_018975.2

UniProt accession no.

Q9NYB0

shipped in

dry ice

Quality Level

100

Gene Information

human ... TERF2IP(54386)

Analysis Note

routinely evaluated by immunoblot analysis

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

A GST-tagged fusion protein, corresponding to amino acids 788-884 of human Ral GDS-Rap binding domain (RBD)
Product Source: expressed in E. coli

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Preparation Note

6 months at -20C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Measurement of GTP-bound Ras-like GTPases by activation-specific probes.
M van Triest et al.
Methods in enzymology, 333, 343-348 (2001-06-13)
Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor
Herrmann, C, et al
The Journal of Biological Chemistry, 271, 6794-6800 (1996)
B Franke et al.
The EMBO journal, 16(2), 252-259 (1997-01-15)
Rap1 is a small, Ras-like GTPase whose function and regulation are still largely unknown. We have developed a novel assay to monitor the active, GTP-bound form of Rap1 based on the differential affinity of Rap1GTP and Rap1GDP for the Rap
Amlodipine potentiates metalloproteinase activity and accelerates elastin degradation in a model of aneurysmal disease.
J R Boyle,I M Loftus,S Goodall,M Crowther,P R Bell,M M Thompson
European Journal of Vascular and Endovascular Surgery null
J F Rebhun et al.
The Journal of biological chemistry, 275(45), 34901-34908 (2000-08-10)
Although the Ras subfamily of GTPases consists of approximately 20 members, only a limited number of guanine nucleotide exchange factors (GEFs) that couple extracellular stimuli to Ras protein activation have been identified. Furthermore, no novel downstream effectors have been identified
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Global Trade Item Number

SKUGTIN
14-45504053252469350
17-32104053252369438

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