14-459-M

Abl Protein, active, mouse, 10 µg

Name: Abl Protein, active, mouse, 10 µg
Brand: MM

Active, recombinant mouse Abl, residues 27-1123, containing N-terminal His-6 tag, for use in Kinase Assays.

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.32

eCl@ss:

32160405

Product Name

Abl Protein, active, mouse, 10 µg, Active, recombinant mouse Abl, residues 27-1123, containing N-terminal His-6 tag, for use in Kinase Assays.

biological source

mouse

recombinant

expressed in baculovirus infected Sf21 cells

mol wt

M_w 123.5 kDa

manufacturer/tradename

Upstate^®

technique(s)

activity assay: suitable (kinase)

Analysis Note

routinely evaluated by phosphorylation of Abltide

Biochem/physiol Actions

Protein Target: Abl

Target Sub-Family: TK

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Product Source: Expressed by baculovirus in Sf21

Recombinant mouse Abl, residues 27-1123, containing N-terminal His6 tag

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Packaging

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-459M when ordering the 250 µg size.

Physical form

Ni²⁺/NTA-agarose

Preparation Note

1 year at -70°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents.

Kharbanda, S, et al.

Nature, 376, 785-788 (1995)

c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines.

B B Brasher et al.

The Journal of biological chemistry, 275(45), 35631-35637 (2000-08-31)

Using the specific Abl tyrosine kinase inhibitor STI 571, we purified unphosphorylated murine type IV c-Abl and measured the kinetic parameters of c-Abl tyrosine kinase activity in a solution with a peptide-based assay. Unphosphorylated c-Abl exhibited substantial peptide kinase activity

Global Trade Item Number

SKU	GTIN
14-459M	04053252733345
14-459	04053252586668

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