14-516-M

Cdk5/p25 Protein, active, 10 µg

Name: Cdk5/p25 Protein, active, 10 µg
Brand: MM

Active complex of N-terminal His6-tagged, recombinant, full-length human Cdk5 & N-terminal GST-tagged, recombinant, full-length human p25, for use in Kinase Assays.

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.32

eCl@ss:

32160405

Product Name

Cdk5/p25 Protein, active, 10 µg, Active complex of N-terminal His6-tagged, recombinant, full-length human Cdk5 & N-terminal GST-tagged, recombinant, full-length human p25, for use in Kinase Assays.

biological source

human

recombinant

expressed in baculovirus infected Sf21 cells

mol wt

M_w 34.4 kDa (cdk5)
M_w 49.4 kDa (p25)

manufacturer/tradename

Upstate^®

technique(s)

activity assay: suitable (kinase)

Analysis Note

routinely evaluated by phosphorylation of Histone H1

Application

Research Category
Metabolism

Research Sub Category
Obesity

Metabolic Disorders

Biochem/physiol Actions

Protein Target: CDK5/p25

Target Sub-Family: CMGC

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Complex of N-terminal His6-tagged, recombinant, full-length human cdk5 and Nterminal GST-tagged, recombinant, full-length human p25

Product Source: Co-expressed by baculovirus in Sf21 insect cells

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Packaging

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-516M when ordering the 250 µg size.

Physical form

Ni²⁺/NTA-agarose

Preparation Note

1 year at -70°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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CDK5 positively regulates Notch1 signaling in pancreatic cancer cells by phosphorylation.

Qiaoyun Chu et al.

Cancer medicine, 10(11), 3689-3699 (2021-05-08)

The marked overexpression of cyclin-dependent kinase 5 (CDK5) or Notch1 receptor, which plays critical roles in pancreatic ductal adenocarcinoma (PDAC) development, has been detected in numerous PDAC cell lines and tissues. Although, a previous study has demonstrated that CDK5 inhibition

Global Trade Item Number

SKU	GTIN
14-516M	04053252673771
14-516	04053252284465

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