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Merck

14-627-M

EGFR (L861Q) Protein, active, 10 µg

Active, N-terminal GST-tagged, recombinant human EGF Receptor, amino acids 696-end containing the mutation L861Q, for use in Enzyme Assays.

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
eCl@ss:
32160405

Product Name

EGFR (L861Q) Protein, active, 10 µg, Active, N-terminal GST-tagged, recombinant human EGF Receptor, amino acids 696-end containing the mutation L861Q, for use in Enzyme Assays.

biological source

human

recombinant

expressed in baculovirus infected Sf21 cells

mol wt

Mw 85.8 kDa

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable

NCBI accession no.

NM_005228.3
NM_201282.1
NM_201283.1
NM_201284.1

UniProt accession no.

P00533

Quality Level

100
300

Analysis Note

routinely evaluated by phosphorylation of 0.1mg/ml Poly (Glu4-Tyr)

Application

Research Category
Inflammation & Immunology

Biochem/physiol Actions

Protein Target: EGFR
Target Sub-Family: TK

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

N-terminal GST-tagged, recombinant human EGF Receptor, amino acids 696-end containing the mutation L861Q
Product Source: baculovirus in Sf21 insect cells

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Physical form

Glutathione-agarose

Preparation Note

6 months at -70°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Thomas J Lynch et al.
The New England journal of medicine, 350(21), 2129-2139 (2004-05-01)
Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which targets the epidermal growth factor receptor (EGFR). However, about 10 percent of patients have a rapid and often dramatic clinical response. The molecular mechanisms

Global Trade Item Number

SKUGTIN
14-62704053252373251

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