14-814
UbcH8 Conjugating Enzyme, 100 µg
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About This Item
UNSPSC Code:
12352204
NACRES:
NA.32
eCl@ss:
32160405
Biological source:
human
biological source
human
Quality Segment
mol wt
Mw 18 kDa
manufacturer/tradename
Upstate®
NCBI accession no.
UniProt accession no.
General description
UbcH8 is a class I ubiquitin-conjugating (E2) enzyme highly similar in structure to UbcH7. UbcH8 is a primary target gene of interferon-alpha and gamma, and recent studies have indicated that UbcH8 is the E2 enzyme for the ubiquitin-like protein ISG15. These studies suggest overlap between the ISG15 and ubiquitin conjugation pathways, and have important implications for understanding the regulation and function of ISG15 in the IFN alpha/beta response. Typical enzyme concentration to support conjugation in vitro is 100nM to 1μM depending upon conditions.
expressed in E. coli
Application
UbcH8 is a class I ubiquitin-conjugating (E2) enzyme highly similar in structure to UbcH7. UbcH8 is a primary target gene of interferon-alpha & gamma.
Physical form
Format: Purified using Ni2+ chelation chromatography with Ni2+ in limiting concentration.
Preparation Note
For long term storage store at -80°C.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial
Storage Class
12 - Non Combustible Liquids
Certificates of Analysis (COA)
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