171262
AMPK Activator V, Ampkinone
The AMPK Activator V, Ampkinone modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Biochemicals applications.
Synonym(s):
AMPK Activator V, Ampkinone, AKN, AMPK Signaling Activator V
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About This Item
Empirical Formula (Hill Notation):
C31H23NO6
CAS Number:
Molecular Weight:
505.52
UNSPSC Code:
12352200
NACRES:
NA.51
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥98% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 25 mg/mL
shipped in
wet ice
storage temp.
2-8°C
SMILES string
OC1=C(OC)C=CC2=C1OC(C)(C)C3=C2C=CC4=C3C(N(C5=CC=C(C(C6=CC=CC=C6)=O)C=C5)C4=O)=O
InChI key
BRRCHDIWBKOMEC-UHFFFAOYSA-N
General description
A cell-permeable benzopyran compound that stimulates both LKB1 and CaMKK-mediated AMPK activity indirectly with no noticeable effect on purified AMPK, cellular AMP/ATP ratio, PI 3-K/Akt signaling and respiratory chain, and displays antidiabetic and antiobesity properties. Shown to induce phosphorylation of AMPK-Thr172 and ACC-Ser79 in L6 cells (EC50 = 4.3 µM), C2C12 myocytes, 3T3-L1 preadipocytes and HepG2 hepatic cells, and enhance glucose uptake and insulin sensitivity in high fat-diet-induced obesity mouse model (10 mg/kg, s.c.) with the lowering of cholesterol and nonesterified fatty acids.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Oh, S., et al. 2010. J. Med. Chem.53, 7405.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Regulatory Review (Z)
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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