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Merck

171372

Amphiregulin, Human, Recombinant

Amphiregulin, Human, Recombinant, consisting of amino acids 101-198 and is expressed in E. coli. Stimulates the proliferation of various human and mouse keratinocytes.

Synonym(s):

Schwannoma-derived growth factor (SDGF)

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About This Item

NACRES:
NA.77
UNSPSC Code:
12352203

Product Name

Amphiregulin, Human, Recombinant, Amphiregulin, Human, Recombinant, consisting of amino acids 101-198 and is expressed in E. coli. Stimulates the proliferation of various human and mouse keratinocytes.

recombinant

expressed in E. coli

assay

≥97% (SDS-PAGE)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

impurities

<1.0 EU/μg protein Endotoxin

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

ED₅₀ = 5-15 ng/ml as measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblasts.

Disclaimer

Toxicity: Standard Handling (A)

General description

Recombinant, human amphiregulin (AR) consisting of amino acids 101-198 and expressed in E. coli. Human amphiregulin is able to stimulate the proliferation of various human and mouse keratinocytes, mammary epithelial cells, and some fibroblasts. Shown to be an autocrine growth factor, amphiregulin is also a growth inhibitor for various tumor cells and can bind to the EGF receptor.

Physical form

Lyophilized from 0.2 µm sterile-filtered PBS, BSA.

Preparation Note

Following reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
Reconstitute to 100 µg/ml in sterile PBS containing at least 0.1% human or bovine serum albumin.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

Certificates of Analysis (COA)

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