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171375

Amphotericin B, Streptomyces sp.

A polyene antifungal antibiotic that non-specifically induces loss of low molecular weight substances from cells. Binds to sterols and disrupts osmotic integrity of fungal membrane. Causes suppression of bone marrow progenitor cells.

Synonym(s):

Amphotericin B, Streptomyces sp., Fungizone

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About This Item

Empirical Formula (Hill Notation):
C47H73NO17
CAS Number:
1397-89-3
Molecular Weight:
924.08
UNSPSC Code:
12352200
MDL number:
MFCD00877763
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Quality Segment

100

assay

>86% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 30-40 mg/mL, DMF: soluble

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5-,9-7-,10-8-,13-11-,14-12-,17-15-,18-16-/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

InChI key

APKFDSVGJQXUKY-ZNVUZQDLSA-N

General description

A polyene antifungal antibiotic that non-specifically induces loss of low molecular weight substances from cells. Binds to sterols and disrupts osmotic integrity of fungal membrane. Causes suppression of bone marrow progenitor cells.
An antifungal agent. A polyene antibiotic that nonspecifically induces the loss of low molecular weight substances from cells. Causes suppression of bone marrow progenitor cells. Probably forms channels by complexing with membrane cholesterol. Effective against fungi and yeast at concentrations of 1-10 µg/ml.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Solutions in tissue culture media are stable for 3 days at 37°C.

Other Notes

Tollemar, J., et al. 1995. Transplantation 59, 45.
Charak, B.S., et al. 1994. Br. J. Haematol. 88, 693.
Barth, C., et al. 1993. J. Biophys.64, 92.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

pictograms

Exclamation mark
GHS07

flash_point_f

Not applicable

flash_point_c

Not applicable

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class

11 - Combustible Solids

target_organs

Respiratory system

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