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Merck

176695

Angeli′s Salt

A nitroxyl anion (NO⁻) donor that spontaneously dissociates in a pH dependent first order process to liberate 0.54 moles of NO per mole of the parent compound.

Synonym(s):

Angeli’s Salt, Sodium α-Oxyhyponitrite, Disodium Diazen-1-ium-1,2,2-triolate, AS, Sodium Trioxodinitrate

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About This Item

Empirical Formula (Hill Notation):
N2O3 · 2Na
CAS Number:
13826-64-7
Molecular Weight:
121.99
MDL number:
MFCD33404171
NACRES:
NA.77
UNSPSC Code:
12352200

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Product Name

Angeli′s Salt, A nitroxyl anion (NO⁻) donor that spontaneously dissociates in a pH dependent first order process to liberate 0.54 moles of NO per mole of the parent compound.

assay

≥99%

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

solubility

alkaline solution: soluble (0.01 M NaOH)

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

Related Categories

Packaging

Packaged under inert gas

Biochem/physiol Actions

Cell permeable: no
Primary Target
Nitroxyl anion (NO-) donor
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

A nitroxyl anion (NO–) donor that spontaneously dissociates in a pH dependent first order process to liberate 0.54 moles of NO per mole of the parent compound. Half-life (t½) in 100 mM phosphate buffer, pH 7.4 is 2.3 minutes at 37°C. Decomposition is nearly instantaneous at pH 5.0.
A nitroxyl anion (NO-) donor that spontaneously, in the presence of oxygen and Cu2+ and Fe3+, dissociates in a pH-dependent, first-order process to liberate 0.54 moles of NO per mole of the parent compound. Half-life (t½) of NO release = 2.3 min. (in 100 mM phosphate buffer, pH 7.4 at 37°C). Induces relaxation of norepinephrine-constricted rabbit aorta (EC50 = 590 nM). Angeli′s Salt produces nitroxyl anion (NO-) that can be converted to NO in the presence of heme.

Other Notes

Miranda, K.M., et al. 2001. J. Biol. Chem.276, 1720.
Hrinczenko, B.W., et al. 2000. Br. J. Haematol.110, 412.
Nelli, S., et al. 2000. Br. J. Pharmacol.131, 356.
Ma, X.L., et al. 1999. Proc. Natl. Acad. Sci. USA96, 14617.
Keefer, L.K., et al. 1996. Methods Enzymol.268, 281.
Fukuto, J.M., et al. 1993. Biochem. Biophys. Res. Commun.196, 707.
Maragos, C.M., et al. 1991. J. Med. Chem.34, 3242.

Preparation Note

Following reconstitution in alkaline solution, store at -20°C. This product is stable for 6 months as supplied. Alkaline stock solutions are stable for up to 24 h at -20°C. Unstable in acidic or neutral pH buffers.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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