Angiostatin K1-3, Human, Recombinant, E. coli

Name: Angiostatin K1-3, Human, Recombinant, <i>E. coli</i>
Brand: MM

Angiostatin K1-3 is a recombinant form expressed in E. coli as a single, non-glycosylated polypeptide chain of 259 amino acids. A specific inhibitor of endothelial cell growth and angiogenesis.

Synonym(s):

Ang K1-3, K1-3, rHuAng K1-3

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About This Item

NACRES:

NA.77

UNSPSC Code:

12352203

Product Name

Angiostatin K1-3, Human, Recombinant, E. coli, Angiostatin K1-3 is a recombinant form expressed in E. coli as a single, non-glycosylated polypeptide chain of 259 amino acids. A specific inhibitor of endothelial cell growth and angiogenesis.

recombinant

expressed in E. coli

assay

≥95% (HPLC and SDS-PAGE)

form

lyophilized powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

solubility

aqueous buffer containing 0.1% BSA: soluble
water: soluble

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

Disclaimer

Toxicity: Standard Handling (A)

General description

Recombinant, human angiostatin expressed in E. coli as a single, nonglycosylated polypeptide chain containing 259 amino acids. Represents a proteolytic fragment containing the first three kringle structures of plasminogen. Acts as a specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED₅₀=70 nM) relative to kringles 1-4 (ED₅₀=135 nm).

Other Notes

Cao, R., et al. 1999. Proc. Natl. Acad. Sci. USA96, 5728.
Cao, E., et al. 1997. J. Biol. Chem.272, 22924.
Sim, B.K., et al. 1997. Cancer Res.57, 1329.
Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun.236, 651.
O′Rieilly, M.S., et al. 1994. Cell79, 315.
Peterson, T.E., et al. 1990. J. Biol. Chem.265, 6104.
Forsgren, M., et al. 1987. FEBS Lett.213, 254.
Malinowski, D.P., et al. 1984. Biochemistry23, 4243.

Physical form

Lyophilized from 20 mM Sodium Acetate, 4% Mannitol, pH 5.5.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

Certificates of Analysis (COA)

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