176880
Anisomycin, Streptomyces griseolus
Strongly activates stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase in mammalian cells.
Synonym(s):
Anisomycin, Streptomyces griseolus, 2-( p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate, 2-(p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate
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About This Item
Empirical Formula (Hill Notation):
C14H19NO4
CAS Number:
Molecular Weight:
265.30
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 100 mg/mL, methanol: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
InChI
1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m0/s1
InChI key
YKJYKKNCCRKFSL-BFHYXJOUSA-N
General description
Activates p54 and MAP kinases. Involved in the activation of stress-activated protein kinases (SAPKs). Synergizes with growth factors to induce c-fos and c-jun by acting as a potent signaling agonist. An inhibitor of protein synthesis at the translation step. Also known to induce apoptosis in the human monoblastoid cell line, U937.
Strongly activates stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase in mammalian cells. Synergizes with growth factors to induce c-fos and c-jun by acting as a potent signaling agonist. An inhibitor of protein synthesis at the translation step. Also known to induce apoptosis in the human monoblastoid cell line, U937.
Preparation Note
Following reconstitution store in the refrigerator (4°C). DMSO stock solutions are stable for up to 6 months at 4°C.
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Hazzalin, C.A., et al. 1998. Mol. Cell. Biol. 18, 1844.
Kardalinou, E., et al. 1994. Mol. Cell. Biol.14, 1066.
Kyriakis, J.M., et al. 1994. Nature 369, 156.
Sanchez, I., et al. 1994. Nature 372, 794.
Shinohara, K., and Oka, T. 1994. NeuroReport 5, 2201.
Kochi, S. K., and Collier, R.J. 1993. Exp. Cell Res.208, 296.
Kardalinou, E., et al. 1994. Mol. Cell. Biol.14, 1066.
Kyriakis, J.M., et al. 1994. Nature 369, 156.
Sanchez, I., et al. 1994. Nature 372, 794.
Shinohara, K., and Oka, T. 1994. NeuroReport 5, 2201.
Kochi, S. K., and Collier, R.J. 1993. Exp. Cell Res.208, 296.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Toxic (F)
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Madeleine Scharf et al.
Molecular and cellular biology, 33(13), 2586-2602 (2013-04-24)
The mitogen-activated protein kinase (MAPK)-activated protein kinases 2 and 3 (MK2/3) represent protein kinases downstream of the p38 MAPK. Using MK2/3 double-knockout (MK2/3(-/-)) mice, we analyzed the role of MK2/3 in cross-striated muscle by transcriptome and proteome analyses and by
James L McLellan et al.
Life science alliance, 7(6) (2024-04-05)
Increasing numbers of antimalarial compounds are being identified that converge mechanistically at inhibition of cytoplasmic translation, regardless of the molecular target or mechanism. A deeper understanding of how their effectiveness as liver stage translation inhibitors relates to their chemoprotective potential
James L McLellan et al.
Bio-protocol, 14(5), e4952-e4952 (2024-03-11)
The Plasmodium parasites that cause malaria undergo an obligate, asymptomatic developmental stage in the host liver before initiating the symptomatic blood-stage infection. The parasite liver stage is a key intervention point for antimalarial chemoprophylaxis: successful targeting of liver-stage parasites prevents