178488
Apoptosis Inhibitor
The Apoptosis Inhibitor, also referenced under CAS 54135-60-3, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.
Synonym(s):
Apoptosis Inhibitor, M50054, 2,2ʹ-Methylenebis(1,3-cyclohexanedione)
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About This Item
Empirical Formula (Hill Notation):
C13H16O4
CAS Number:
Molecular Weight:
236.26
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated
color
off-white
solubility
DMSO: 100 mg/mL, ethanol: 20 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
O=C1CCCC(=O)C1CC2C(=O)CCCC2=O
InChI
1S/C13H16O4/c14-10-3-1-4-11(15)8(10)7-9-12(16)5-2-6-13(9)17/h8-9H,1-7H2
InChI key
ILUMEPMGPCKGHH-UHFFFAOYSA-N
General description
A cell-permeable inhibitor of apoptosis induction (IC50 = 67 µg/ml in FasL-stimulated WC8 cells, 130 µg/ml in etoposide-stimulated U937 cells). Effects attributable to the inhibition of caspase-3 activation but does not directly inhibit caspase-3 even at 1 mg/ml.
A cell-permeable, bis(cyclohexane-1,3-diketone) that is shown to inhibit apoptosis induction in FasL-stimulated WC8 cells (IC50 = 67 µg/ml) and etoposide-stimulated U937 cells (IC50 = 130 µg/ml). The anti-apoptotic effects have been shown to be attributable to inhibition of caspase-3 activation (IC50 = 334 nM), however it does not exhibit any direct inhibition of caspase-3 enzymatic activity. Shown to inhibit the elevation of the liver enzymes, alanine aminotransferase and aspartate aminotransferase, in a murine model of anti-Fas-induced hepatitis. Topical application has been shown to reduce chemotherapy-induced alopecia (hair loss) in newborn rats.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
apoptosis induction
apoptosis induction
Product does not compete with ATP.
Reversible: no
Target IC50: 67 µg/ml in FasL-stimulated WC8 cells, 130 µg/ml in etoposide-stimulated U937 cells
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Tsuda, T., et al. 2001. Eur. J. Pharmacol.433, 37.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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