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Merck

189513

Autotaxin Inhibitor IV, HA155

The Autotaxin Inhibitor IV, HA155 controls the biological activity of Autotaxin. This small molecule/inhibitor is primarily used for Cell Structure applications.

Synonym(s):

Autotaxin Inhibitor IV, HA155, Atx Inhibitor IV, HA155, ( Z)-4-((4-((3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan-5-yliden)-methyl)phenoxy)methyl)benzeneboronic acid, Atx Inhibitor IV, HA155, (Z)-4-((4-((3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan-5-yliden)-methyl)phenoxy)methyl)benzeneboronic acid

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About This Item

Empirical Formula (Hill Notation):
C24H19BFNO5S
CAS Number:
Molecular Weight:
463.29
UNSPSC Code:
41121800
NACRES:
NA.28
MDL number:
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Product Name

Autotaxin Inhibitor IV, HA155, The Autotaxin Inhibitor IV, HA155 controls the biological activity of Autotaxin. This small molecule/inhibitor is primarily used for Cell Structure applications.

InChI key

BRWUZCBSWABPMR-XKZIYDEJSA-N

SMILES string

O=C(/C(S1)=C/C2=CC=C(OCC3=CC=C(B(O)O)C=C3)C=C2)N(CC4=CC=C(F)C=C4)C1=O

assay

≥99% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

yellow

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

Disclaimer

Toxicity: Standard Handling (A)

General description

A ~5-fold more potent (IC50 = 5.7 nM) para-isomer boronate analog of Autotaxin Inhibitor II, HA130 (Cat. No. 189511) that efficiently blocks thrombin-stimulated lysophosphatidic acid secretion in platelets and in mammalian cells.

Other Notes

Fulkerson, Z., et al. 2011. J. Biol. Chem.286, 34654.
Hausmann, J., et al. 2011. Nat. Struct. Mol. Biol.18, 198.
Albers, H.M.H.G., et al. 2011. J. Med. Chem.54, 4619.
Albers, H.M.H.G., et al. 2010. J. Med. Chem.53, 4958.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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