191501
1-Azakenpaullone
InSolution, ≥94%, ATP-competitive inhibitor of GSK-3Beta
Synonym(s):
InSolution 1-Azakenpaullone
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About This Item
Empirical Formula (Hill Notation):
C15H10BrN3O
CAS Number:
Molecular Weight:
328.16
UNSPSC Code:
12352200
MDL number:
Assay:
≥94% (HPLC)
Form:
liquid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Level
assay
≥94% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
shipped in
dry ice
storage temp.
−20°C
InChI
1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)
InChI key
NTSBZVCEIVPKBJ-UHFFFAOYSA-N
General description
A Kenpaullone (Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC50 = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC50 = 2.0 µM and 4.2 µM, respectively). The solid form of this compound (Cat. No. 191500 ) is also available.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
GSK-3β
GSK-3β
Reversible: yes
Target IC50: 18 nM for GSK-3&beta
Packaging
Packaged under inert gas
Physical form
A 10 mM (500 µg/152 µL) solution of 1-Azakenpaullone (Cat. No. 191500 ) in DMSO.
Preparation Note
Following initial thaw, aliquot and freeze. Aliquots are stable for up to 6 months at -20°C.
Other Notes
Kunick, C., et al. 2004. Bioorg. Med. Chem. Lett.14, 413.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - closed cup - (refers to pure substance)
flash_point_c
87 °C - closed cup - (refers to pure substance)
Certificates of Analysis (COA)
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