197220
Bcl-2 Binding Peptide, Cell-Permeable
A cell-permeable peptide that binds to Bcl-2 with high affinity (IC50 = 130 nM in a competition binding study) and induces apoptosis.
Synonym(s):
Bcl-2 Binding Peptide, Cell-Permeable, cpm-1285, Decanoyl-KN¹⁴⁰LWAAQRYGRELRRMSDEFEGSFKGL¹⁶⁵-OH
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About This Item
Empirical Formula (Hill Notation):
C153H240N44O42S
Molecular Weight:
3399.88
UNSPSC Code:
12352202
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic)
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
off-white
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Packaging
Packaged under inert gas
Physical form
Supplied as a trifluoroacetate salt.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Bcl-2
Bcl-2
Product does not compete with ATP.
Reversible: no
Target IC50: 130 nM against Bcl-2
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell-permeable Bcl-2 binding peptide that induces apoptosis in Bcl-2 expressing cells with no apparent effect on normal peripheral lymphocytes. Also reported to diminish the growth of human myeloid leukemia in severe combined immunodeficient mice. The peptide is derived from the BH3 domain (residues 140-165, a death domain) of Bad and is modified to be cell-permeable by attaching a decanoyl moiety at the N-terminus.
A cell-permeable peptide that binds to Bcl-2 with high affinity (IC50 = 130 nM in a competition binding study) and induces apoptosis. Displays antitumor activity in cells overexpressing Bcl-2 with no apparent effect on normal peripheral lymphocytes. The peptide is derived from the BH3 domain (residues 140 - 165, a “death domain”) of Bad and is modified to be cell permeant by attaching a decanoyl moiety at the N-terminus.
Other Notes
CH₃(CH₂)₈CONH-Lys-Asn-Leu-Trp-Ala-Ala-Gln-Arg-Tyr-Gly-Arg-Glu-Leu-Arg-Arg-Met-Ser-Asp-Glu-Phe-Glu-Gly-Ser-Phe-Lys-Gly-Leu-OH
Wang, J-L., et al. 2000. Cancer Res.60, 1498.
Kelekar, A., et al. 1997. Mol. Cell. Biol.17, 7040.
Kelekar, A., et al. 1997. Mol. Cell. Biol.17, 7040.
Preparation Note
Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 weeks at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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