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Merck

200488

Bestatin Hydrochloride

InSolution, ≥98%, a metalloprotease inhibitor

Synonym(s):

InSolutionBestatin, Hydrochloride, [(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-Leu, HCl

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About This Item

Empirical Formula (Hill Notation):
C16H24N2O4 · xHCl
Molecular Weight:
308.37 (free base basis)
UNSPSC Code:
12352202
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
liquid
Quality level:
100
Storage condition:
OK to freeze
avoid repeated freeze/thaw cycles
protect from light

Key Documents

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Product Name

Bestatin Hydrochloride, InSolution, ≥98%, a metalloprotease inhibitor

SMILES string

CC(C)C[C@@H](C(O)=O)NC([C@@H](O)[C@H](N)CC1=CC=CC=C1)=O.[xHCl]

assay

≥98% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles
protect from light

shipped in

dry ice

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: no
Primary Target
Metalloproteases
Reversible: yes

Disclaimer

Toxicity: Standard Handling (A)

General description

A metalloprotease inhibitor. Reversibly binds to cell surfaces and competitively inhibits surface aminopeptidases, notably aminopeptidase B and leucine aminopeptidase. Also acts as a potent aminopeptidase N inhibitor. Activates macrophages and T lymphocytes. Has anti-tumor properties. Effective at a concentration of 1-10 µM. The solid form of this compound (Cat. No. 200484) is also available.

Other Notes

Merck Index: 14, 9842.
Inoue, T., et al. 1994. J. Clin. Endocrinol. Metab.79, 171.
Taylor, A., et al. 1993. Biochemistry32, 784.
Ishida, J.I., et al. 1984. J. Chromatogr.305, 381.
Umezawa, H. 1982. Annu. Rev. Microbiol.36, 75.

Packaging

Packaged under inert gas

Physical form

Supplied as a 50 mM (10 mg/580 µL) solution of Bestatatin, HCl in H₂O.

Preparation Note

Following initial, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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