Skip to Content
Merck

203709

Insulin Expression Inducer, BRD7389

A cell-permeable naphthoquinolinedione compound that specifically induces insulin secretion in mouse αTC1-cells and promotes transdifferentiation to a β-cell-like status.

Synonym(s):

Insulin Expression Inducer, BRD7389, 1-((2-Phenylethyl)amino)-3H-naphtho[1,2,3-de]quinoline-2,7-dione, Insulin Receptor-Related Protein Inhibitor, IRR Inhibitor, INSRR Inhibitor, RSK Inhibitor III

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C24H18N2O2
CAS Number:
376382-11-5
Molecular Weight:
366.41
MDL number:
MFCD02924820
UNSPSC Code:
12352200
NACRES:
NA.51
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze
protect from light

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Insulin Expression Inducer, BRD7389, A cell-permeable naphthoquinolinedione compound that specifically induces insulin secretion in mouse αTC1-cells and promotes transdifferentiation to a β-cell-like status.

SMILES string

[nH]1c2c3c(c5c([c](c3ccc2)=O)cccc5)c([c]1=O)NCCc4ccccc4

InChI

1S/C24H18N2O2/c27-23-17-10-5-4-9-16(17)21-20-18(23)11-6-12-19(20)26-24(28)22(21)25-14-13-15-7-2-1-3-8-15/h1-12,25H,13-14H2,(H,26,28)

InChI key

XASCINRGTHLHGM-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

orange-yellow

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Disclaimer

Toxicity: Regulatory Review (Z)

General description

A cell-permeable naphthoquinolinedione compound that is reported to preferentially inhibit 23 kinases (IC50 ≤10 µM) from a panel of 219, notably IRR (h), CLK2(h), Rsk1(h), Flt3(h), Rsk1(r), Rsk2(h), Haspin(h), Rsk4(h), Melk(h), Drak1(h), Rsk3(h), and CK13(h) (% inhibition by 10 µM BRD7389 = 91, 87, 86, 79, 78, 76, 74, 73, 73, 72, 71, and 71, respectively). Shown to induce β-cell-like morphology in cultured murine pancreatic α-cell αTC1 and stimulate the expression of insulin mRNA (by ~50-fold; 0.85 µM for 5 d) and protein (by 1.5-fold; 3.4 µM for 5 d), as well as other β-cell mRNAs, including Iapp, Npy, Pdx1, and Pax4, in αTC1 cultures. In human primary islets cultures, BRD7389 treatments result in a decrease of overall cell counts over time due to apoptosis induction, while insulin-positive population, and in some cases also glucagon-positive cell population, remains more or less unaffected.

Other Notes

Fomina-Yadlin, D., et al. 2010. Proc. Natl. Acad. Sci. USA107, 15099.

Packaging

Packaged under inert gas

Preparation Note

Following recontitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service