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Merck

204879

Complement C1s, Human, Activated, Two-Chain Form

Complement C1s, Human, Activated, Two-Chain Form, CAS 80295-35-8, is a native, activated form. Activated C1s continues activation via classical pathway by cleaving, and thus activating, C2 and C4.

Synonym(s):

Complement C1s, Human, Activated, Two-Chain Form

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About This Item

CAS Number:
80295-35-8
MDL number:
MFCD00004689
NACRES:
NA.25
UNSPSC Code:
12352202

Product Name

Complement C1s, Human, Activated, Two-Chain Form, Complement C1s, Human, Activated, Two-Chain Form, CAS 80295-35-8, is a native, activated form. Activated C1s continues activation via classical pathway by cleaving, and thus activating, C2 and C4.

assay

≥95% (SDS-PAGE)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

shipped in

wet ice

storage temp.

−70°C

Quality Level

100

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Toxicity: Standard Handling (A)

General description

Native, human, activated C1s complement component. Present in human serum at 31 µg/ml. Nonactivated C1s is found in circulating blood plasma as a Ca2+-dependent dimer in association with one C1q molecule and two C1r molecules to form the first component of complement (C1). Ensuing C1q binding to classical complement pathway activators, each C1r protein is cleaved to form activated C1r enzyme. Dimeric C1r enzyme cleaves, and thus activates, each C1s molecule into two disulfide-linked fragments of M.W. 59 kDa and 28 kDa. The 28 kDa peptide contains the C1s enzymatic active site. Activated C1s continues activation via classical pathway by cleaving, and thus activating, C2 and C4.

Other Notes

Cooper, N.R. 1985. Adv. Immunol. 37, 151.
Sim, R.B. 1981. Methods Enzymol. 80, 6.

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In 130 mM NaCl, 50 mM sodium phosphate, pH 7.2.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C).
Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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