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Merck

211280

Capsazepine

≥97% (HPLC), Capsaicin and resiniferatoxin antagonist, solid

Synonym(s):

Capsazepine, N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide

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About This Item

Empirical Formula (Hill Notation):
C19H21ClN2O2S
CAS Number:
138977-28-3
Molecular Weight:
376.90
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00153778

Product Name

Capsazepine, A competitive antagonist of Capsaicin and resiniferatoxin. Capsazepine (1 µM) blocks capsaicin (60 nM) stimulated firing of C-fibers.

SMILES string

S=C(N2CCCc3c(cc(c(c3)O)O)C2)NCCc1ccc(cc1)Cl

InChI

1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)

InChI key

DRCMAZOSEIMCHM-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

off-white

solubility

DMSO: soluble
methanol: soluble

shipped in

ambient

storage temp.

10-30°C

Quality Level

100

Related Categories

Disclaimer

Toxicity: Standard Handling (A)

Biochem/physiol Actions

Cell permeable: no
Primary Target
A competitive antagonist of Capsaicin and resiniferatoxin
Product does not compete with ATP.
Reversible: no

General description

A competitive antagonist of Capsaicin (Cat. No. 211274) and resiniferatoxin. Capsazepine (1 µM) blocks capsaicin (60 nM) stimulated firing of C-fibers.
A competitive antagonist of the sensory neuron excitants capsaicin (Cat. No. 211274) and resiniferatoxin (Cat. No. 553975). Capsazepine (1 µM) blocks capsaicin (60 nM) stimulated firing of C-fibers.

Other Notes

Fox, A.J., et al. 1995. Neuroscience 67, 741.
Ellis, J.L., and Undem, B.J. 1994. J. Pharmacol. Exp. Ther. 268, 85.
Walpole, C.S.J., et al. 1994. J. Med. Chem.37, 1942.
Szallasi, A., et al. 1993. J. Pharmacol. Exp. Therap.267, 728.

Preparation Note

Unstable in solution; reconstitute just prior to use.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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