217460
Cardiogenol C
A cell-permeable pyrimidine compound that potently induces the differentiation of ESCs (embryonic stem cells) into cardiomyocytes (EC50 = 100 nM) without significant cytotoxic effect even at concentrations as high as 25 µM.
Synonym(s):
Cardiogenol C, 2-(4-Methoxyanilino)-4-(1-hydroxyethylamino)pyrimidine
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About This Item
Empirical Formula (Hill Notation):
C13H16N4O2
CAS Number:
Molecular Weight:
260.29
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
InChI
1S/C13H16N4O2.ClH/c1-19-11-4-2-10(3-5-11)16-13-15-7-6-12(17-13)14-8-9-18;/h2-7,18H,8-9H2,1H3,(H2,14,15,16,17);1H
InChI key
QQAHYSZVJLHCNA-UHFFFAOYSA-N
General description
A cell-permeable pyrimidine compound that potently induces the differentiation of ESCs (embryonic stem cells) into cardiomyocytes (EC50 = 100 nM) without significant cytotoxic effect even at concentrations as high as 25 µM. The induction of cardiomyogenesis by Cardiogenol C is much more efficient than that achieved by EBs (embryoid bodies) formation and DMSO treatment.
Biochem/physiol Actions
Cell permeable: yes
EC50 = 100 nM inducing the differentiation of ESCs (embryonic stem cells) into cardiomyocytes
Primary Target
Differentiation of ESCs (embryonic stem cells) into cardiomyocytes
Differentiation of ESCs (embryonic stem cells) into cardiomyocytes
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Wu, X., et al. 2004. J. Am. Chem. Soc.126, 1590.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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