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Merck

217460

Cardiogenol C

A cell-permeable pyrimidine compound that potently induces the differentiation of ESCs (embryonic stem cells) into cardiomyocytes (EC50 = 100 nM) without significant cytotoxic effect even at concentrations as high as 25 µM.

Synonym(s):

Cardiogenol C, 2-(4-Methoxyanilino)-4-(1-hydroxyethylamino)pyrimidine

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About This Item

Empirical Formula (Hill Notation):
C13H16N4O2
CAS Number:
671225-39-1
Molecular Weight:
260.29
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
MFCD06798334

Key Documents

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Product Name

Cardiogenol C, A cell-permeable pyrimidine compound that potently induces the differentiation of ESCs (embryonic stem cells) into cardiomyocytes (EC50 = 100 nM) without significant cytotoxic effect even at concentrations as high as 25 µM.

InChI

1S/C13H16N4O2.ClH/c1-19-11-4-2-10(3-5-11)16-13-15-7-6-12(17-13)14-8-9-18;/h2-7,18H,8-9H2,1H3,(H2,14,15,16,17);1H

InChI key

QQAHYSZVJLHCNA-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Product does not compete with ATP.
Reversible: no
Primary Target
Differentiation of ESCs (embryonic stem cells) into cardiomyocytes
Cell permeable: yes
EC50 = 100 nM inducing the differentiation of ESCs (embryonic stem cells) into cardiomyocytes

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

General description

A cell-permeable pyrimidine compound that potently induces the differentiation of ESCs (embryonic stem cells) into cardiomyocytes (EC50 = 100 nM) without significant cytotoxic effect even at concentrations as high as 25 µM. The induction of cardiomyogenesis by Cardiogenol C is much more efficient than that achieved by EBs (embryoid bodies) formation and DMSO treatment.

Other Notes

Wu, X., et al. 2004. J. Am. Chem. Soc.126, 1590.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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