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Merck

217695

Cdk1 Inhibitor - CAS 220749-41-7 - Calbiochem

The Cdk1 Inhibitor, also referenced under CAS 220749-41-7, controls the biological activity of Cdk1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

Cdk1 Inhibitor - CAS 220749-41-7 - Calbiochem, 3-(2-Chloro-3-indolylmethylene)-1,3-dihydroindol-2-one

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About This Item

Empirical Formula (Hill Notation):
C17H11ClN2O
CAS Number:
220749-41-7
Molecular Weight:
294.74
UNSPSC Code:
12352200

Key Documents

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Product Name

Cdk1 Inhibitor - CAS 220749-41-7 - Calbiochem, The Cdk1 Inhibitor, also referenced under CAS 220749-41-7, controls the biological activity of Cdk1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

orange

solubility

DMSO: 200 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Cdk1
Product competes with ATP.
Reversible: yes
Target IC50: 2 µM for anti-proliferative properties in HeLa cells; 5.8 µM against Cdk1/cyclin B

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable indolylmethylene-2-indolinone derivative that exhibits potent anti-proliferative properties (IC50 = 2 µM HeLa cells). Acts as a selective, reversible and ATP-competitive inhibitor of Cdk1/cyclin B (IC50 = 5.8 µM). Also inhibits Cdk5 with a IC50 = 25 µM. Binds to the ATP pocket on the Cdk1 active site. Does not affect the activity of GSK-3β even at 100 µM concentrations.
A cell-permeable indolylmethylene-2-indolinone derivative that exhibits potent anti-proliferative properties (IC50 = 2 µM in HeLa cells). Acts as a selective, reversible and ATP-competitive inhibitor of cyclin-dependent kinase-1/cyclin B (IC50 = 5.8 µM for Cdk1 and 25 µM for Cdk5). Does not affect the activity of GSK-3β even at 100 µM concentrations. Binds to the ATP pocket in the Cdk1 active site.

Other Notes

Andreani, A., et al. 2000. Anticancer Drug Des.15, 447.
Andreani, A., et al. 1996. Anticancer Res.16, 3585.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10-13 - German Storage Class 10 to 13

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Stefanie Schmetsdorf et al.
The European journal of neuroscience, 29(6), 1096-1107 (2009-03-24)
Cyclins and cyclin-dependent kinases (Cdks) are the main components that control the orderly progression through cell cycle. In the mature nervous system, terminally differentiated neurons are permanently withdrawn from cell cycle, as mitotic quiescence is essential for the functional stability

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