Cdk1 Inhibitor - CAS 220749-41-7 - Calbiochem

A cell-permeable indolylmethylene-2-indolinone derivative that exhibits potent anti-proliferative properties (IC₅₀ = 2 µM HeLa cells). Acts as a selective, reversible and ATP-competitive inhibitor of Cdk1/cyclin B (IC₅₀ = 5.8 µM). Also inhibits Cdk5 with a IC₅₀ = 25 µM. Binds to the ATP pocket on the Cdk1 active site. Does not affect the activity of GSK-3β even at 100 µM concentrations.

A cell-permeable indolylmethylene-2-indolinone derivative that exhibits potent anti-proliferative properties (IC₅₀ = 2 µM in HeLa cells). Acts as a selective, reversible and ATP-competitive inhibitor of cyclin-dependent kinase-1/cyclin B (IC₅₀ = 5.8 µM for Cdk1 and 25 µM for Cdk5). Does not affect the activity of GSK-3β even at 100 µM concentrations. Binds to the ATP pocket in the Cdk1 active site.

Cell permeable: yes

Primary Target
Cdk1

Product competes with ATP.

Reversible: yes

Target IC₅₀: 2 µM for anti-proliferative properties in HeLa cells; 5.8 µM against Cdk1/cyclin B

Packaged under inert gas

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Andreani, A., et al. 2000. Anticancer Drug Des.15, 447.
Andreani, A., et al. 1996. Anticancer Res.16, 3585.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)