218710
Casein Kinase II Inhibitor III, TBCA
The Casein Kinase II Inhibitor III, TBCA, also referenced under CAS 934358-00-6, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
Casein Kinase II Inhibitor III, TBCA, (E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid, CKII Inhibitor, TBCA
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About This Item
Empirical Formula (Hill Notation):
C9H4Br4O2
CAS Number:
Molecular Weight:
463.74
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.54
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (HPLC)
form
solid
potency
110 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 10 mg/mL (Use only fresh DMSO.), ethanol: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
Brc1c(c(cc(c1Br)\C=C\C(=O)O)Br)Br
InChI
1S/C9H4Br4O2/c10-5-3-4(1-2-6(14)15)7(11)9(13)8(5)12/h1-3H,(H,14,15)/b2-1+
InChI key
SVJQCVOKYJWUBC-OWOJBTEDSA-N
General description
A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC50 = 7.7 µM). Also available as a 25 mM solution in DMSO (Cat. No. 218861).
Biochem/physiol Actions
Cell permeable: yes
Product competes with ATP.
Reversible: no
Target Ki: 77 nM against Casein Kinase II
Packaging
Packaged under inert gas
Other Notes
Pagano, M.A., et al. 2006. Chembiochem8, 129
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
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Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class
11 - Combustible Solids
WGK
WGK 2
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