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Merck

218714

Casein Kinase II Inhibitor IX, IQA

The Casein Kinase II Inhibitor IV, also referenced under CAS 391670-48-7, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

Casein Kinase II Inhibitor IX, IQA, 5-Oxo-5,6-dihydroindolo[1,2-a]quinazoline-7-acetic acid

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About This Item

Empirical Formula (Hill Notation):
C17H12N2O3
CAS Number:
391670-48-7
Molecular Weight:
292.29
UNSPSC Code:
12352200

Product Name

Casein Kinase II Inhibitor IX, IQA, The Casein Kinase II Inhibitor IV, also referenced under CAS 391670-48-7, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

InChI key

DNABALWBHCYRNL-UHFFFAOYSA-N

InChI

1S/C17H12N2O3/c20-15(21)9-12-10-5-1-3-7-13(10)19-14-8-4-2-6-11(14)17(22)18-16(12)19/h1-8,12H,9H2,(H,20,21)

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

light yellow

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable indoloquinazolinone compound that acts as a potent, selective, and reversible CK2 inhibitor (IC50 = 390 nM with 100 M ATP) in an ATP- and GTP-competitive manner (Ki = 0.17 and 0.21 M, respectively). IQA exhibits much reduced activity against PI 3-Kα/β/γ (No inhibition at 20 M) and 48 commonly studied protein kinases (IC50 ≥10 M with 100 M ATP) and is more selective than TBB (Cat. Nos. 218697 and 218708) with respect to DYRK1a (IC50 = 8 and <1 M, respectively, with 100 M ATP).

Other Notes

Piazza, F.A., et al. 2006. Blood108, 1698.
Di Maira, G., et al. 2005. Cell Death Differ.12, 668.
Sarno, S., et al. 2003. Biochem. J.374, 639.
Vangrevelinghe, E., et al. 2003. J. Med. Chem.46, 2656.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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