218714
Casein Kinase II Inhibitor IX, IQA
The Casein Kinase II Inhibitor IV, also referenced under CAS 391670-48-7, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
Casein Kinase II Inhibitor IX, IQA, 5-Oxo-5,6-dihydroindolo[1,2-a]quinazoline-7-acetic acid
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About This Item
Empirical Formula (Hill Notation):
C17H12N2O3
CAS Number:
Molecular Weight:
292.29
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
light yellow
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
InChI
1S/C17H12N2O3/c20-15(21)9-12-10-5-1-3-7-13(10)19-14-8-4-2-6-11(14)17(22)18-16(12)19/h1-8,12H,9H2,(H,20,21)
InChI key
DNABALWBHCYRNL-UHFFFAOYSA-N
General description
A cell-permeable indoloquinazolinone compound that acts as a potent, selective, and reversible CK2 inhibitor (IC50 = 390 nM with 100 M ATP) in an ATP- and GTP-competitive manner (Ki = 0.17 and 0.21 M, respectively). IQA exhibits much reduced activity against PI 3-Kα/β/γ (No inhibition at 20 M) and 48 commonly studied protein kinases (IC50 ≥10 M with 100 M ATP) and is more selective than TBB (Cat. Nos. 218697 and 218708) with respect to DYRK1a (IC50 = 8 and <1 M, respectively, with 100 M ATP).
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Other Notes
Piazza, F.A., et al. 2006. Blood108, 1698.
Di Maira, G., et al. 2005. Cell Death Differ.12, 668.
Sarno, S., et al. 2003. Biochem. J.374, 639.
Vangrevelinghe, E., et al. 2003. J. Med. Chem.46, 2656.
Di Maira, G., et al. 2005. Cell Death Differ.12, 668.
Sarno, S., et al. 2003. Biochem. J.374, 639.
Vangrevelinghe, E., et al. 2003. J. Med. Chem.46, 2656.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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