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218718

Sigma-Aldrich

Casein Kinase II Inhibitor VI, TMCB

The Casein Kinase II Inhibitor VI, TMCB, also referenced under CAS 905105-89-7, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

Casein Kinase II Inhibitor VI, TMCB, ERK8 Inhibitor I, 4,5,6,7- Tetrabromo-2-di methylamino-1- carboxymethyl- benzimidazole, K66, Erk Inhibitor VI, ERK8 Inhibitor I, 4,5,6,7-Tetrabromo-2-dimethylamino-1-carboxymethyl-benzimidazole, K66, Erk Inhibitor VI

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About This Item

Empirical Formula (Hill Notation):
C11H9Br4N3O2
CAS Number:
905105-89-7
Molecular Weight:
534.82
UNSPSC Code:
12352200
NACRES:
NA.54

Quality Level

100

Assay

≥97% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 13.3 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C11H9Br4N3O2/c1-17(2)11-16-9-7(14)5(12)6(13)8(15)10(9)18(11)3-4(19)20/h3H2,1-2H3,(H,19,20)

InChI key

PHAOTASRLQMKBE-UHFFFAOYSA-N

General description

A cell-permeable tertabromobenzimidazolo TBB (Cat. Nos. 218699 and 218708) analog that acts as a highly selective (IC50 >10 µM against 71 other kinases) ATP-competitive inhibitor against CK2 (IC50 = 500 nM; Ki = 250 nM) and ERK8 (IC50 = 500 nM). K66 is reported to be more selective than either TBB or DMAT and selective CK2 inhibition by K66 is shown to be cytotoxic to non-ERK8-expressing Jurkat cells.

Packaging

Packaged under inert gas

Other Notes

Pagano, M.A., et al. 2008. Biochem. J.415, 353.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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