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218718

Casein Kinase II Inhibitor VI, TMCB

Name: Casein Kinase II Inhibitor VI, TMCB
Brand: MM

The Casein Kinase II Inhibitor VI, TMCB, also referenced under CAS 905105-89-7, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

Casein Kinase II Inhibitor VI, TMCB, ERK8 Inhibitor I, 4,5,6,7- Tetrabromo-2-di methylamino-1- carboxymethyl- benzimidazole, K66, Erk Inhibitor VI, ERK8 Inhibitor I, 4,5,6,7-Tetrabromo-2-dimethylamino-1-carboxymethyl-benzimidazole, K66, Erk Inhibitor VI

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₉Br₄N₃O₂

CAS Number:

905105-89-7

Molecular Weight:

534.82

UNSPSC Code:

12352200

NACRES:

NA.54

Assay:

≥97% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

OK to freeze, protect from light

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Properties

Quality Level

100

assay

≥97% (HPLC)

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 13.3 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C11H9Br4N3O2/c1-17(2)11-16-9-7(14)5(12)6(13)8(15)10(9)18(11)3-4(19)20/h3H2,1-2H3,(H,19,20)

InChI key

PHAOTASRLQMKBE-UHFFFAOYSA-N

Description

General description

A cell-permeable tertabromobenzimidazolo TBB (Cat. Nos. 218699 and 218708 ) analog that acts as a highly selective (IC₅₀ >10 µM against 71 other kinases) ATP-competitive inhibitor against CK2 (IC₅₀ = 500 nM; K_i = 250 nM) and ERK8 (IC₅₀ = 500 nM). K66 is reported to be more selective than either TBB or DMAT and selective CK2 inhibition by K66 is shown to be cytotoxic to non-ERK8-expressing Jurkat cells.

Packaging

Packaged under inert gas

Other Notes

Pagano, M.A., et al. 2008. Biochem. J.415, 353.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c