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218728

Caspase-9 Inhibitor III

Name: Caspase-9 Inhibitor III
Brand: MM

The Caspase-9 Inhibitor III, also referenced under CAS 403848-57-7, controls the biological activity of Caspase-9. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):

Caspase-9 Inhibitor III, Ac-LEHD-CMK

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₃₅ClN₆O₉

CAS Number:

403848-57-7

Molecular Weight:

587.02

MDL number:

MFCD02259690

UNSPSC Code:

12352200

NACRES:

NA.54

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, desiccated

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Properties

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated

color

white

solubility

water: 1 mg/mL, DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

ClCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)CCC(=O)O)Cc1nc[nH]c1)CC(=O)O

InChI

1S/C24H35ClN6O9/c1-12(2)6-17(28-13(3)32)23(39)29-15(4-5-20(34)35)22(38)31-18(7-14-10-26-11-27-14)24(40)30-16(8-21(36)37)19(33)9-25/h10-12,15-18H,4-9H2,1-3H3,(H,26,27)(H,28,32)(H,29,39)(H,30,40)(H,31,38)(H,34,35)(H,36,37)/t15-,16-,17-,18-/m0/s1

InChI key

JSRLQUNMFYXVQD-XSLAGTTESA-N

Description

General description

A potent and irreversible inhibitor of caspase-9 (ICE-LAP6, Mch6). Reported to reduce myocardial infarct size during reperfusion (~70 nM).

A potent, irreversible inhibitor of caspase-9. Reported to reduce myocardial infarct size during reperfusion (~70 nM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
caspase-9

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 70 nM against caspase-9

Other Notes

Ac-Leu-Glu-His-Asp-CMK

Mocanu, M.M., et al. 2000. Br. J. Pharmacol.130, 197.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c