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Merck

218753

Caspase-5 Inhibitor I

Single spot by TLC, solid, Caspase-5 inhibitor, Calbiochem®

Synonym(s):

Caspase-5 Inhibitor I, Z-WE(OMe)HD(OMe)-FMK

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About This Item

Empirical Formula (Hill Notation):
C37H42FN7O10
Molecular Weight:
763.77
UNSPSC Code:
12352200
NACRES:
NA.77

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Product Name

Caspase-5 Inhibitor I, Z-WEHD-FMK is a cell-permeable, potent, irreversible caspase-5 inhibitor, that also inhibits the activity of Caspase 1, 4, and 8.

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

Analysis Note

single spot by TLC

Biochem/physiol Actions

Cell permeable: yes
Primary Target
caspase-1, caspase-4, caspase-5, caspase-8
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

A potent, cell-permeable and irreversible inhibitor of caspase-5 (ICErel-III, TY), as well as caspase-1 and caspase-4.
A potent, cell-permeable, and irreversible inhibitor of caspase-5. Strongly inhibits caspase-1. Also inhibits caspase-4 and caspase-8.

Other Notes

Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Rano, T., et al. 1997. Chem. Biol. 4, 149.
Z-Trp-Glu(OMe)-His-Asp(OMe)-CH₂F*

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 4 months at 4°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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