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Merck

218830

Caspase Inhibitor II, Cell-Permeable - Calbiochem

The Caspase Inhibitor II, Cell-Permeable controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):

Caspase Inhibitor II, Cell-Permeable - Calbiochem, cpm-VAD-CHO; sequence

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About This Item

Empirical Formula (Hill Notation):
C88H151N19O22
Molecular Weight:
1827.25
UNSPSC Code:
12352200

Key Documents

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Product Name

Caspase Inhibitor II, Cell-Permeable - Calbiochem, The Caspase Inhibitor II, Cell-Permeable controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

Biochem/physiol Actions

Cell permeable: yes
Primary Target
caspase-1-like proteases
Reversible: yes

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable, reversible pan-caspase inhibitor produced by attaching the N-terminal sequence (amino acids 1-16) of the Kaposi fibroblast growth factor signaling peptide, which imparts cell-permeability to VAD peptide.
A cell-permeable, reversible inhibitor of caspase-1-like proteases. Constructed by attaching the N-terminal sequence (amino acids 1-16) of the Kaposi fibroblast growth factor signaling peptide to Caspase Inhibitor II (Cat. No. 218735), which imparts cell-permeability to this peptide.

Other Notes

Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Ala-Asp-CHO
Thornberry, N.A., and Lazebnik, Y. 1998. Science281, 1312.
Lin, Y-Z., et al. 1996. J. Biol. Chem.271, 5305.
Lin, Y-Z., et al. 1995. J. Biol. Chem.270, 14255.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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