218830
Caspase Inhibitor II, Cell-Permeable - Calbiochem
The Caspase Inhibitor II, Cell-Permeable controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.
Synonym(s):
Caspase Inhibitor II, Cell-Permeable - Calbiochem, cpm-VAD-CHO; sequence
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About This Item
Empirical Formula (Hill Notation):
C88H151N19O22
Molecular Weight:
1827.25
UNSPSC Code:
12352200
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A cell-permeable, reversible inhibitor of caspase-1-like proteases. Constructed by attaching the N-terminal sequence (amino acids 1-16) of the Kaposi fibroblast growth factor signaling peptide to Caspase Inhibitor II (Cat. No. 218735), which imparts cell-permeability to this peptide.
A cell-permeable, reversible pan-caspase inhibitor produced by attaching the N-terminal sequence (amino acids 1-16) of the Kaposi fibroblast growth factor signaling peptide, which imparts cell-permeability to VAD peptide.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
caspase-1-like proteases
caspase-1-like proteases
Reversible: yes
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Ala-Asp-CHO
Thornberry, N.A., and Lazebnik, Y. 1998. Science281, 1312.
Lin, Y-Z., et al. 1996. J. Biol. Chem.271, 5305.
Lin, Y-Z., et al. 1995. J. Biol. Chem.270, 14255.
Lin, Y-Z., et al. 1996. J. Biol. Chem.271, 5305.
Lin, Y-Z., et al. 1995. J. Biol. Chem.270, 14255.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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