Skip to Content
Merck

218861

Casein Kinase II Inhibitor III, TBCA

InSolution, ≥90%

Synonym(s):

InSolution Casein Kinase II Inhibitor III, TBCA, ( E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid, (E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C9H4Br4O2
CAS Number:
934358-00-6
Molecular Weight:
463.74
UNSPSC Code:
12352200
NACRES:
NA.54
MDL number:
MFCD20921901
Assay:
≥90% (HPLC)
Form:
liquid
Quality level:
100
Storage condition:
OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

InChI

1S/C9H4Br4O2/c10-5-3-4(1-2-6(14)15)7(11)9(13)8(5)12/h1-3H,(H,14,15)/b2-1+

SMILES string

OC(/C=C/C1=CC(Br)=C(Br)C(Br)=C1Br)=O

InChI key

SVJQCVOKYJWUBC-OWOJBTEDSA-N

assay

≥90% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

shipped in

dry ice

storage temp.

−70°C

Quality Level

100

Related Categories

General description

A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than TBB (Cat. No. 218697 and Cat. No. 218708) and DMAT against a panel of 28 commonly studied kinases. Shown to efficiently induce apoptosis in Jurkat cells (DC50 = 7.7 µM). The solid form of this compound (Cat. No. 218710) is also available.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
CKII
Reversible: yes

Packaging

Packaged under inert gas

Physical form

A 25 mM (5 mg/431 µL) solution of Casein Kinase II Inhibitor III, TBCA (Cat. No. 218710) in DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Other Notes

Pagano, M.A., et al. 2006. Chembiochem,8, 129.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup - (refers to pure substance)

flash_point_c

87 °C - closed cup - (refers to pure substance)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Mario A Pagano et al.
Chembiochem : a European journal of chemical biology, 8(1), 129-139 (2006-11-30)
Abnormally high constitutive activity of protein kinase CK2, levels of which are elevated in a variety of tumours, is suspected to underlie its pathogenic potential. The most widely employed CK2 inhibitor is 4,5,6,7-tetrabromobenzotriazole (TBB), which exhibits a comparable efficacy toward

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service