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Merck

219370

Coagulation Factor VIIa, Human Plasma

Coagulation Factor VIIa, Human Plasma, is a native coagulation factor VIIa prepared from human Factor VII using human Factor XIIa, which was removed after activation.

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About This Item

EC Number:
3.4.21.21 (BRENDA, IUBMB)
NACRES:
NA.25
UNSPSC Code:
12352202

Product Name

Coagulation Factor VIIa, Human Plasma, Coagulation Factor VIIa, Human Plasma, is a native coagulation factor VIIa prepared from human Factor VII using human Factor XIIa, which was removed after activation.

assay

≥95% (SDS-PAGE)

form

liquid

specific activity

≥25,000 PEU/mg protein (clotting assay)

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

shipped in

wet ice

storage temp.

−70°C

Quality Level

100

Analysis Note

Clotting activity is determined by comparison to a standard curve produced using normal pooled human plasma

Disclaimer

Toxicity: Standard Handling (A)

General description

Native coagulation factor VIIa from human plasma prepared from human Factor VII using human Factor XIIa, which was removed after activation. In the coagulation process, after complexing with tissue factor and membrane phospholipids, Factor VIIa activates Factors IX and X to the enzymatically active Factors IXa and Xa. Provides a crossover point between the extrinsic and intrinsic pathways.

Other Notes

Broze, G.J. 1994. In Haemostasis and Thrombosis, 3rd Edition(Bloom, et al. Eds.) Churchill Livingstone, Edinburgh, p 349.
Majerus, P.W., et al. 1990. In The Pharmacological Basis of Therapeutics, 8th Edition (Gilman, A.G., et al. Eds.) Pergamon Press, New York, p 1311.

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In 100 mM NaCl, 20 mM Tris-HCl, pH 7.5.

Preparation Note

Following initial use aliquot and freeze (-70°C).
Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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