219399

Cathepsin D Substrate I

Name: Cathepsin D Substrate I
Brand: MM

Useful as a substrate for the determination of cathepsin D activity.

Synonym(s):

Cathepsin D Substrate I, Bz-RGFFP-4-MeOβNA, HCl

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About This Item

Empirical Formula (Hill Notation):

C₄₉H₅₅N₉O₇ · xHCl

Molecular Weight:

882.02 (free base basis)

NACRES:

NA.77

UNSPSC Code:

51111800

Product Name

Cathepsin D Substrate I, Useful as a substrate for the determination of cathepsin D activity.

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
desiccated
protect from light

color

white

solubility

DMSO: 5 mg/mL

fluorescence

λ_ex ~345 nm
λ_em ~425 nm

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

Bioactive Small Molecule Inhibitors

Biochem/physiol Actions

Cell permeable: no

Primary Target
Substrate for the determination of cathepsin D activity

Product does not compete with ATP.

Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

A useful substrate for colorimetric or fluorometric assay of cathepsin D activity. Cathepsin D hydrolyzes the Phe-Phe bond. Dipeptidyl aminopeptidase II is required to free the 4-methoxy-β-naphthylamine (4MβNA). Excitation max: ~345 nm; emission max: ~425 nm.

Useful as a substrate for the determination of cathepsin D activity. Suitable for either colorimetric or fluorometric assay. Cathepsin D hydrolyzes the Phe-Phe bond. Requires dipeptidyl aminopeptidase II to free 4-methoxy-β-naphthylamine (4MeOβNA).

Other Notes

Bz-Arg-Gly-Phe-Phe-Pro-4MeOβNA, HCl

Takahashi, T., and Tang, J. 1981. Methods Enzymol.80, 565.
Smith, R.E., and Van Frank, R.M. 1975. in Lysosomes in Biology and Pathology4 (Dingle, J.T., and Dean, R.T., eds.) p. 193, American Elsevier, Holland.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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