219404
Cathepsin H, Human Liver
Cathepsin H, Human Liver, CAS 60748-73-4, is native cathepsin H from human liver that functions both as an aminopeptidase and as an endopeptidase.
Synonym(s):
Cathepsin H, Human Liver, CTSH, cat H, procathepsin h
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About This Item
CAS Number:
NACRES:
NA.77
UNSPSC Code:
12352202
MDL number:
Specific activity:
≥200 mU/mg protein
Quality Level
description
Merck USA index - 14, 1905
form
liquid
specific activity
≥200 mU/mg protein
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles
technique(s)
activity assay: suitable
color
colorless
pH
4.5
solubility
soluble, water: soluble
suitability
suitable for Western blot
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−70°C
Gene Information
human ... CTSH(1512)
General description
Research area: Cell signaling
Native Cathepsin H, from the human liver, is the only cathepsin with mono-aminopeptidase activity.
Native Cathepsin H, from the human liver, is the only cathepsin with mono-aminopeptidase activity.
Application
Cathepsin H has been used to determine the potential of aziridinyl peptides to act as inhibitors of this protein and potentially explore their therapeutic applications.
Biochem/physiol Actions
Cathepsin H, derived from human liver, serves dual functions as both an aminopeptidase and an endopeptidase. It plays a significant role in the catabolism of proteins within lysosomes. Cathepsin H is classified as an endoaminopeptidase because it can hydrolyze proteins, N-terminal substituted proteins, amino acid derivatives, and peptides with different chain lengths and N-terminal free amino acid derivatives. This protein is also observed to exhibit amidase and esterase activity.
Packaging
Please refer to vial label for lot-specific concentration.
Physical form
In 100 mM NaCl, 20 mM sodium acetate buffer, 1 mM EDTA, pH 4.5.
Preparation Note
Following initial thaw, aliquot and freeze (-70°C).
Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Other Notes
Note: 1 mU = 1 milliunit.
One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol H-Arg-βNA per min at 40°C, pH 6.8.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Related Content
New peptidic cysteine protease inhibitors derived from the electrophilic alpha-amino acid aziridine-2,3-dicarboxylic acid
Schirmeister T
Journal of Medicinal Chemistry, 42, 560-572 (1999)
Cathepsin H: an endoaminopeptidase from rat liver lysosomes
Acta Biologica Et Medica Germanica, 36(2), 185-199 (1977)