219404

Cathepsin H, Human Liver

Name: Cathepsin H, Human Liver
Brand: MM

Cathepsin H, Human Liver, CAS 60748-73-4, is native cathepsin H from human liver that functions both as an aminopeptidase and as an endopeptidase.

Synonym(s):

Cathepsin H, Human Liver, CTSH, cat H, procathepsin h

Select a Size

All Photos(1)

About This Item

CAS Number:

60748-73-4

EC Number:

3.4.22.16 (BRENDA, IUBMB)

NACRES:

NA.77

UNSPSC Code:

12352202

MDL number:

MFCD09878269

Product Name

Cathepsin H, Human Liver, Cathepsin H, Human Liver, CAS 60748-73-4, is native cathepsin H from human liver that functions both as an aminopeptidase and as an endopeptidase.

description

Merck USA index - 14, 1905

form

liquid

specific activity

≥200 mU/mg protein

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

technique(s)

activity assay: suitable

color

colorless

pH

4.5

solubility

soluble
water: soluble

suitability

suitable for Western blot

NCBI accession no.

NM_004390

UniProt accession no.

P09668

shipped in

wet ice

storage temp.

−70°C

Quality Level

100

Gene Information

human ... CTSH(1512)

Application

Cathepsin H has been used to determine the potential of aziridinyl peptides to act as inhibitors of this protein and potentially explore their therapeutic applications.

Biochem/physiol Actions

Cathepsin H, derived from human liver, serves dual functions as both an aminopeptidase and an endopeptidase. It plays a significant role in the catabolism of proteins within lysosomes. Cathepsin H is classified as an endoaminopeptidase because it can hydrolyze proteins, N-terminal substituted proteins, amino acid derivatives, and peptides with different chain lengths and N-terminal free amino acid derivatives. This protein is also observed to exhibit amidase and esterase activity.

Disclaimer

Toxicity: Standard Handling (A)

General description

Research area: Cell signaling

Native Cathepsin H, from the human liver, is the only cathepsin with mono-aminopeptidase activity.

Other Notes

Note: 1 mU = 1 milliunit.

One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol H-Arg-βNA per min at 40°C, pH 6.8.

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In 100 mM NaCl, 20 mM sodium acetate buffer, 1 mM EDTA, pH 4.5.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C).

Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Cathepsin H: an endoaminopeptidase from rat liver lysosomes

Acta Biologica Et Medica Germanica, 36(2), 185-199 (1977)

New peptidic cysteine protease inhibitors derived from the electrophilic alpha-amino acid aziridine-2,3-dicarboxylic acid

Schirmeister T

Journal of Medicinal Chemistry, 42, 560-572 (1999)