219419
Cathepsin Inhibitor III
The Cathepsin Inhibitor III controls the biological activity of Cathepsin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Synonym(s):
Cathepsin Inhibitor III, Z-FG-NHO-BzOME
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About This Item
Empirical Formula (Hill Notation):
C27H27N3O7
Molecular Weight:
505.52
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
>90% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, desiccated, protect from light
Quality Level
assay
>90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated, protect from light
color
white
solubility
ethanol: 1 mg/mL, DMSO: 5 mg/mL
shipped in
ambient
storage temp.
10-30°C
General description
Cysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 1.0 x 104 M-1sec-1), cathepsin L (k2/Ki = 1.5 x 105 M-1sec-1), cathepsin S (k2/Ki = 6.6 x 104 M-1sec-1), and papain (k2/Ki = 1.0 x 103 M-1sec-1). Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).
Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).
Biochem/physiol Actions
Cell permeable: no
Primary Target
cathepsin B
cathepsin B
Product does not compete with ATP.
Reversible: no
k₂/Ki = 1 x 10⁴ M⁻¹ sec⁻¹
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta1295, 179.
Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.
Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.
Z-Phe-Gly-NHO-Bz-pOMe
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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