219445
Cdk2 Inhibitor II
The Cdk2 Inhibitor II, also referenced under CAS 222035-13-4, controls the biological activity of Cdk2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
Cdk2 Inhibitor II, Compound 3
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About This Item
Empirical Formula (Hill Notation):
C14H11BrN4O3S
CAS Number:
Molecular Weight:
395.23
UNSPSC Code:
12352200
Assay:
≥95% (sum of two isomers, HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
assay
≥95% (sum of two isomers, HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Cell permeable: yes
Primary Target
CDK2
CDK2
Product competes with ATP.
Reversible: yes
Target IC50: 60 nM against Cdk2
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell-permeable, reversible, ATP-competitive, potent and selective inhibitor of Cdk2 (IC50 = 60 nM).
Other Notes
Davis, S.T., et al. 2001. Science291, 134.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition.
Zonderland, et al.
Molecular Cell, 82, 3350-3365 (2022)
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