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Merck

23-046-M

Parkin (c-Myc tagged) Protein, active, 10 µg

Active, full length, recombinant human Parkin. N-terminal c-Myc, 6His-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

Synonym(s):

Parkinson juvenile disease protein 2, PARK2, PRKN

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.43
eCl@ss:
32160405

Product Name

Parkin (c-Myc tagged) Protein, active, 10 µg, Active, full length, recombinant human Parkin. N-terminal c-Myc, 6His-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

biological source

human

recombinant

expressed in baculovirus infected Sf21 cells

product line

Upstate®

purified by

affinity chromatography

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable

accession no.

NM_004562

NCBI accession no.

NM_004562

Quality Level

100

Application

Ubiquitination Cascade Comoponent: E3

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Parkin is an E3-ubiquitin ligase belonging to the RBR (RING – In Between RING – RING) family. Mutations in Parkin that result in a loss-of-function are the most frequent cause of familial Parkinson’s disease and are responsible for a large percentage of autosomal recessive juvenile parkinsonism (AR-JP). In addition to its auto-ubiquitination, Parkin can also ubiquitinate various substrates, including the CDK2-interacting protein cyclin E1, the α-synuclein-interacting protein synphilin-1, the synaptic vesicle-associated CDC-rel1 and the p38 subunit of aminoacyl-tRNA synthetase/JTV-1. Ubiquitination of substrates occurs in conjunction with the E2 enzymes UbcH7, UbcH8 or UbcH13/Uev1.

Physical form

Purified using immobilized metal affinity chromatography.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1

Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_c

Not applicable

Certificates of Analysis (COA)

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