233156
Cleland′s Reagent, Molecular Biology Grade
A protective agent for SH groups.
Synonym(s):
Cleland’s Reagent, Molecular Biology Grade, 1,4-Dithiothreitol, DTT
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About This Item
Empirical Formula (Hill Notation):
C4H10O2S2
CAS Number:
Molecular Weight:
154.25
UNSPSC Code:
12161504
NACRES:
NA.25
MDL number:
Assay:
≥99% (titration)
Form:
powder, solid
grade
Molecular Biology
Quality Segment
description
Merck USA index - 14, 3376
assay
≥99% (titration)
form
powder, solid
reaction suitability
reagent type: reductant
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
water: 15 mg/mL
cation traces
heavy metals: ≤0.001%
absorption
≤0.100 at 280 nm at 100 mM (1 cm), ≤0.500 at 260 nm at 100 mM (1 cm)
foreign activity
DNases, proteases, RNases, none detected
shipped in
ambient
storage temp.
2-8°C
SMILES string
SC[C@H](O)[C@@H](O)CS
InChI
1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m0/s1
InChI key
VHJLVAABSRFDPM-IMJSIDKUSA-N
General description
Water-soluble protective reagent for sulfhydryl groups [absorbance (100 mM): ≤0.5 at 260 nm; ≤0.1 at 280 nm]. It is capable of maintaining monothiols completely in the reduced state and of reducing disulfides quantitatively. Since it readily permeates cell membranes, it can protect protein sulfhydryls and restore enzyme activity lost by oxidation.
A protective agent for SH groups.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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