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Human Collagen Type I

Name: Human Collagen Type I
Brand: MM

from human skin, powder

Synonym(s):

Collagen, Type I, Human Skin

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About This Item

CAS Number:

9007-34-5

MDL number:

MFCD00003075

UNSPSC Code:

12352202

NACRES:

NA.77

Biological source:

human skin

Form:

lyophilized

Assay:

≥95% (SDS-PAGE)

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Properties

Product Name

Collagen, Type I, Human Skin,

biological source

human skin

Quality Segment

100

assay

≥95% (SDS-PAGE)

form

lyophilized

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

dilution

(compatible for the preparation of collagen gels)

impurities

≤0.1% subdermal hair

solubility

acetic acid: 5 mg/mL (0.5M)

shipped in

ambient

storage temp.

2-8°C

Description

General description

Collagen type 1 is a fibrillar collagen present abundantly in skin, bone, vasculature, and calcified tissues of teeth and bone. It is also seen in organs like the heart and lungs. Collagen type 1 is a heterotrimer consisting of two α1 (CIα1) and one α2 (CIα2) chains with a helical region made of repeating units of proline and hydroxyproline.

Application

Collagen Type I, Human Skin has been used as a skin protein to study the effect of age-related NADH oxidase (ar-NOX)-catalyzed oxidation on skin proteins. It has also been used as a control sample in High-resolution mass spectrometry (HRMS) analysis.

Biochem/physiol Actions

Collagen type 1 is a main component of the dermal extracellular matrix (ECM) and participates in skin elasticity. Mutations in collagen type 1 are associated with osteogenesis imperfecta and Ehlers–Danlos syndrome.

Physical form

Salt-free.

Preparation Note

Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

The recommended concentration is 0.01 to 0.5 M Acetic Acid (or another acidic buffer), with a maximum concentration of 5 mg/ml. The product has been tested at 0.5 M Acetic Acid and is stable for 1 month at 2-8°C. After reconstitution, aliquot and freeze at -20°C. Stock solutions remain stable for up to 6 months at this temperature.

Other Notes

Gallop, P.M., and Siefert, S. 1963. Methods Enzymol. 6, 635.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Storage Class

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)