234491
PD 153035
InSolution, ≥97%, potent and specific inhibitor of the tyrosine kinase activity of EGFR
Synonym(s):
InSolution PD 153035
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About This Item
Empirical Formula (Hill Notation):
C16H14BrN3O2
Molecular Weight:
360.21
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
liquid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Segment
assay
≥97% (HPLC)
form
liquid
potency
25 pM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
shipped in
wet ice
storage temp.
2-8°C
General description
An extremely potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation.
Biochem/physiol Actions
Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target Ki: 6 pM against the tyrosine kinase activity of the epidermal growth factor receptor (EGFR)
Packaging
Packaged under inert gas
Physical form
A 10 mM (500 µg/139 µl) solution of PD 153035 (Cat. No. 234490 ) in DMSO.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
Certificates of Analysis (COA)
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