234505
Compound 56 - CAS 171745-13-4 - Calbiochem
A cell-permeable, reversible, ATP-competitive, highly potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (IC50 = 6 pM).
Synonym(s):
Compound 56 - CAS 171745-13-4 - Calbiochem, 4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline
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About This Item
Empirical Formula (Hill Notation):
C18H18BrN3O2
CAS Number:
Molecular Weight:
388.26
UNSPSC Code:
12352200
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 200 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A cell-permeable, reversible, ATP-competitive, highly potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 6 pM).
A cell-permeable, reversible, ATP-competitive, highly potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (IC50 = 6 pM).
Biochem/physiol Actions
Primary Target
EGFR
EGFR
Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target IC50: 6 pM against EGFR
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Bridges, A.J., et al. 1996. J. Med. Chem. 39, 267.
Legal Information
Sold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
Storage Class
11 - Combustible Solids
wgk
WGK 3
Certificates of Analysis (COA)
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