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235135

Corticosterone

Name: Corticosterone
Brand: MM

≥95% (HPLC), crystalline powder, corticosteroid hormone, Calbiochem

Synonym(s):

Corticosterone, (11β)-11,21-Dihydroxypregn-4-ene-3,20-dione, Reichstein’s substance H

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₃₀O₄

CAS Number:

50-22-6

Molecular Weight:

346.46

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00037715

Assay:

≥95% (HPLC)

Form:

crystalline powder

Storage condition:

OK to freeze

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Properties

Product Name

Corticosterone, Corticosteroid hormone synthesized in response to stress.

Quality Segment

100

description

Merck USA index - 14, 2538

assay

≥95% (HPLC)

form

crystalline powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

off-white, white to tan

solubility

ethanol: 50 mg/mL

shipped in

ambient

storage temp.

10-30°C

SMILES string

O[C@@H]1[C@H]2[C@H]([C@H]4[C@@]([C@H](CC4)C(=O)CO)(C1)C)CCC3=CC(=O)CC[C@@]32C

InChI

1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

InChI key

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

Description

General description

Corticosteroid hormone synthesized in response to stress. Binds to and activates mineralocorticoid and glucocorticoid receptors, resulting in altered genomic expression. Steroid-induced changes in protein synthesis eventually affect ionic conductances through the membrane. Also induces apoptosis in murine bone marrow.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Mineralocorticoid and glucocorticoid receptors

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Garvy, B.A., et al. 1993. Immunology80, 587.
DeKloet, E.R. 1992. Ann. N.Y. Acad. Sci.663, 357.
Joels, M., and deKloet, E.R. 1992. Trends Neurosci.15, 25.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

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Storage Class

11 - Combustible Solids

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WGK 3

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