238100
CRM1 Inhibitor III
The CRM1 Inhibitor III controls the biological activity of CRM1. This small molecule/inhibitor is primarily used for Cell Structure applications.
Synonym(s):
CRM1 Inhibitor III, (Z)-But-2-enedioic acid (4ʹ-bromophenyl)amide (3ʹʹ-chlorophenyl)amide, Chromosome Region Maintenance 1 ProteinInhibitor III, Exportin 1 Inhibitor III, XPO1 Inhibitor III
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About This Item
Empirical Formula (Hill Notation):
C16H12BrClN2O2
CAS Number:
Molecular Weight:
379.64
UNSPSC Code:
12352200
NACRES:
NA.28
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 100 mg/mL
shipped in
wet ice
storage temp.
2-8°C
SMILES string
O=C(NC1=CC=CC(Cl)=C1)/C=C\C(NC2=CC=C(Br)C=C2)=O
InChI key
GGMKSZQCUBFLME-HJWRWDBZSA-N
General description
A cell-permeable butenediamide compound that acts as a potent, active site cysteine reactive irreversible inhibitor of CRM1/exportin 1. Shown to selectively repress agonist-mediated nuclear export of HDAC4/5, Rev and NFAT proteins in neonatal rat ventricular myocytes (NRVMs; EC50 = 2.2 and 3.5 nM for GFP-HDAC5 and GFP-HIV Rev) and suppress hypertrophic growth of NRVMs (EC50 = 52 nM for ANF expression inhibition) with negligible effect either on the phosphorylation of HDAC5 or on the kinase activities of PKD and CaMKII at 1 µM.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Monovich, L., et al. 2009. Biochim Biophys Acta.1789, 422.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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